8例乳腺微腺腺病临床病理分析及免疫表型特征

Clinicopathological features and immunophenotype of microglandular adenosis of the breast

目的观察乳腺微腺腺病的临床病理特点及免疫表型特征。方法回顾性分析8例乳腺微腺腺病的临床表现、组织形态学及免疫表型特征资料。结果 8例均为女性,平均年龄(30±8.1)岁。B超发现乳腺实质性病变,其中2例伴小灶钙化。光镜下见,小而一致的腺管不规则地分布于间质及脂肪组织中,无实性或梁状结构,无肌上皮细胞层,见一层厚的基底膜;腺体被覆小而一致的单层立方上皮或扁平上皮细胞;胞浆内常有空泡或呈颗粒状;未见浆分泌的"小突起";腺腔内含有酸性分泌物。免疫组化表型:CK(AE1/AE3)、S100、Laminin、CollageⅣ均阳性;CK34β12、EMA、SMA、ER、PR、cerBb-2、P53、Ki67均阴性。结论乳腺微腺腺病较为罕见,好发于中青年女性,有恶变潜能,手术完整切除预后好。

Objective To explore the clinicopathological features and immuno phenotype of microglandular adenosis（MGA）of the breast.Methods Eight cases of MGA of the breast were studied with conventional histopathological and immunohistochemical stains.Results The aveage age of all the eight women was（30±8.1）years.There were two cases of calcified lesion detection in eight cases of breast Masses with Ultrasonography.Histologically,It was characterized by a concentrated proliferation of round glands with open lumens in a densely homogeneous stroma that clearly delineated microglandular adenosis from the adjacent uninvolved breast.The glands were lined by a single layer of cells with distinctly vacuolated or granular cytoplasm.The single layer of epithelial cells lacked cytoplasmic protrusions and was surrounded by a thick multilayered basement membrane.MGA of the breast was immunohistochemically positive for CK（AE1/AE3）,S100,Laminin,and CollageⅣ,and negative for CK34β12,EMA,SMA,ER,PR,C-erbB-2,P53 and Ki67.Conclusion MGA of the breast is an uncommon tumor preferentially involved in middle-age women.The malignant potential of MGA of the breast is stressed,and complete surgical resection is recommended in therapy.