胱抑素C评价肾小球滤过率作用的研究

Investigation on diagnostic value of Cystatin C on renal dysfunction

目的:探讨血清胱抑素C(CysC)评价肾小球滤过率(GFR)和肾功能不全的价值。方法:采用颗粒增强透射免疫比浊法测定508例患者血清CysC,通过MDRD公式计算GFR,比较CysC、血尿素氮(BUN)和肌酐(Cr)与GFR的相关性,比较三者诊断肾功能不全的灵敏度和特异度。结果:相对于BUN和Cr,CysC与GFR有更好的相关性,且CysC诊断肾功能不全的灵敏度和特异度均高于BUN和Cr(P<0.05)。结论:CysC是评价GFR的良好指标,也是诊断早期肾功能不全敏感的指标。

Objective： To investigate the value of Cystatin C（CysC） on evaluating glomerular filtration rate（GFR） and re-nal dysfunction.Methods： CysC of 508 patients with the injury of renal function was measured by immunoturbidimetry,GFR was calculated through MDRD formula.The correlation between CysC,blood urea nitrogen（BUN）,creatinine（Cr） and GFR was compared,and sensitivity and specificity were compared in diagnosing renal dysfunction.Results： CysC dis-played more accordant correlation with GFR than BUN and Cr.CysC was more sensitive and specific in diagnosing renal dysfunction than BUN and Cr（P0.05）.Conclusion： CysC is a good index of evaluating GRF,and it is also a signal of ear-ly stage of renal dysfunction.