奥美拉唑联合西沙必利治疗反流性食管炎72例临床观察

Effect of Omeprazole combined with Cisapride on reflux esophagitis

目的:观察奥美拉唑联合西沙必利治疗反流性食管炎的疗效。方法:将72例患者随机分为观察组(36例)和对照组(36例),观察组,奥美拉唑每日2次,每次20 mg;西沙必利每日3次,每次5 mg。对照组,雷尼替丁每日2次,每次150 mg;西沙必利每日3次,每次5 mg。分别于治疗后观察反酸、胸痛、烧心等症状疗效,并于8周后复查胃镜,观察镜下愈合率。结果:观察组有效率为94.4%,对照组有效率为61.1%,两组比较有显著性差异(P<0.05)。结论:奥美拉唑联合西沙必利治疗反流性食管炎比雷尼替丁联合西沙必利具有更好的疗效。

Objective： To study the efficacy of Omeprazole and Cisapride in treating reflux esophagitis.Method： 72 cases of digestive out-patients were diagnosed with reflux esophagitis（all by biopsy diagnosis）,and randomly divided into two groups,36 cases in observation group,20 mg of Omeprazole,bid,5 mg of Cisapride were taken orally,tid;36 cases in control group,150 mg of Ranitidine,bid,5 mg of Cisapride were taken orally,tid.During the course 8 weeks of treatment,72 cases were checked by the gastroscope at the end of 8 weeks.Results： The clinical curative rates were 94.4% in observation group and 61.1% in control group.Conclusion： The efficacy of Omeprazole and Cisapride in treating reflux esophagitis is obviously superior to the other group.