进展期胃癌血清VEGF-C的表达与其侵袭和淋巴道转移的关系

Expression and significance of serum vascular endothelial growth factor C in advanced gastric carcinoma.

目的研究进展期胃癌患者血清中血管内皮生长因子C(VEGF-C)的水平,并了解其与进展期胃癌的侵袭和淋巴道转移的关系。方法采用酶联免疫技术(ELISA法)检测88例进展期胃癌患者,根据术后病理证实伴淋巴结转移组50例,不伴淋巴结转移组38例,10例早期胃癌患者,10例胃溃疡患者术前血清VEGF-C的水平,并探讨其与进展期胃癌的侵袭与淋巴道转移的关系。结果进展期胃癌血清中VEGF-C的水平明显高于胃溃疡组(P<0.05),和早期胃癌组比较,差异无统计学意义(P>0.05)。在进展期胃癌患者中,随胃癌浸润深度的增加,浸润深度为T3～T4组明显高于T1～T2组(P<0.05)。低分化型癌的患者血清VEGF-C水平明显高于高、中分化型癌的患者(P<0.05)。而在性别、肿瘤位置、组织病理类型方面比较,差异无统计学意义(P>0.05)。伴淋巴结转移组血清VEGF-C的阳性率明显高于不伴淋巴结转移组(P<0.05)。结论血清中高水平的VEGF-C与进展期胃癌的侵袭和淋巴道转移密切相关,血清VEGF-C可作为进展期胃癌的标记物,对术前判定淋巴结转移具有一定的临床价值。

Objective To clarify serum level of Vascular endothelial growth factor C and its relationship with invasion and lymph node metastasis in advanced gastric carcinoma.Methods We classified 88 patients with advanced gastric carcinom,divided into positive lymph node metastasis group of 50 patients and negtive lymph node metastasis group of 38 patients according to pathology after operation.10 patients with early gastric carcinoma,10 patients with gastric Ulceration,used enzyme-labeled immunosorbent assay method to check level of VEGF-C in these groups.Results The serum level of VEGF-C in AGC was higher obiously than gastric Ulceration grup（P0.05） but have no significance with EGC（P0.05）.Soakage type in AGC was higher remarkably than Ulceration type（P0.05）,low tissue differentiation in AGC was much higher than high and middle tissue differentiation（P0.05）,but there was no statistice significance in gender,location of carcinoma,and pathology type（P0.05）.Positve rate of serum VEGF-C in positive lymph node group was much higher than negtive group（P0.05）.Conclusion The high level of serum VEGF-C closely correlation to invasion and lymph node metastasis of AGC.The serum level of VEGF-C had potential usefulness as biologic markers of Advanced gastric carcinoma.