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核苷(酸)类似物抗乙型肝炎病毒耐药的分子机制与临床对策 被引量:3

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摘要 核苷(酸)类似物可以有效抑制乙型肝炎病毒的复制,但长期治疗过程中易出现耐药。因此加强对核苷(酸)类似物耐药的分子机制和耐药对策的研究很有必要。选择合适的患者,采用联合治疗,加强治疗过程中的监控、预测和管理可减少耐药的发生。
作者 杨静 朱萱
出处 《海南医学》 CAS 2010年第21期116-118,共3页 Hainan Medical Journal
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  • 1Bartholomeusz A, Locarnini SA. Antiviral drug resistance: clinical consequences and molecular aspects. Semin Liver Dis, 2006, 26: 162-170.
  • 2Tenney DJ, Levine SM, Rose RE, et al. Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine. Antimicrob Agents Chemother, 2004, 48: 3498-3507.
  • 3Pawlotsky JM, Dusheiko G, Hatzakis A, et al. Virologic monitoring of hepatitis B virus therapy in clinical trials and practice: recommendations for a standardized approach. Gastroenterology, 2008, 134: 405-415.
  • 4Lai CL, Gane E, Hsu CW, et al. Two-year results from the GLOBE trial in patients with hepatitis B: greater clinical and antiviral efficacy for telbivudine (LdT) vs lamivudine. Hepatology, 2006, 44 (Suppl 1): 222A.
  • 5Lau GK, Piratvisuth T, Luo KX, et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B. N Engl J Med, 2005, 352: 2682-2695.
  • 6Marcellin P, Lau GK, Bonino F, et al. Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B. N Engl J Med, 2004, 351: 1206-1217.
  • 7Sung JY, Lai JY, Zeuzem S, et al. A randomized double-blind phase Ⅱ study of lamivudine compared to lamivudine plus adefovir dipivoxil for treatment naive patients with chronic hepatitis B: week 52 analysis. J Hepatol, 2003: 38(suppl 2): 25-26.
  • 8Lai CL, Leung N, Teo EK, et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B. Gastroenterology, 2005, 129: 528- 536.
  • 9Locarnini S, Mason WS. Cellular and virological mechanisms of HBV drug resistance. J Hepatol, 2006, 44: 422-431.
  • 10Lok AS, Zoulim F, Locarnini S, et al. Antiviral drug-resistant HBV: standardization of nomenclature and assays and recommendations for management. Hepatology, 2007, 46: 254-265.

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