摘要
目的研究黄连解毒汤对动脉粥样硬化大鼠主动脉组织MCP-1/CCR2mRNA表达的影响。方法建立动脉粥样硬化大鼠模型,随机分成正常对照组、模型对照组和黄连解毒汤低,中,高剂量组,阿托伐他汀组,用RT-PCR方法检测各实验组大鼠主动脉组织MCP-1,CCR2 mRNA表达。结果与模型组相比,黄连解毒汤中,高剂量组及阿托伐他汀组的MCP-1 mRNA、CCR2 mRNA表达明显降低,结果有显著性差异(P<0.05～0.01)。结论黄连解毒汤能下调MCP-1,CCR2 mRNA在主动脉的表达,减少局部炎症反应,减轻血管的损害。
Objective To study the effect of Huanglian Jiedu Decoction on the expression of MCP-1/CCR2 mRNA in rats with atherosclerosis（AS）.Methods After the AS model was established,AS rats were divided into model group,low-,middle-and high-dosage Huanglian Jiedu Decoction groups and atorvastati group.Meanwhile,a normal control group was also set up.The expression of MCP-1/CCR2 mRNA in aorta was tested by RT-PCR method.Results Compared with the model group,the expression of aortic MCP-1/CCR2 mRNA was significantly 1ower in middle-and high-dosage Huanglian Jiedu Decoction groups and in atorvastati group（P〈0.05 or P〈0.01）.Conclusion Huanglian Jiedu Decoction can decrease the expression of MCP-1/CCR2 mRNA in aorta,reduce local inflammatory reaction,and relieve the aortic damage.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2010年第6期583-586,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广东省中医药管理局项目(2007139)
