局部热疗联合化疗治疗晚期胰腺癌疗效观察

The Observation of Clinical Effectiveness of Hyperthermia Combined with Chemotherapy in Treating Advanced Pancreatic Cancer

目的探讨局部热疗联合健择+顺铂方案治疗晚期复治型胰腺癌的协同增效作用。方法 38例晚期胰腺癌患者,均为经过一线化疗后复发患者,KPS评分60～70分,接受健择+顺铂,并在化疗的第2、5、9天接受肿瘤局部区域热疗,温度41℃～43℃,持续60min。结果 38例中有效30例,疾病控制率78.95%。常见的不良反应为胃肠道毒性,白细胞及血小板减少,其他与化疗相关的不良反应程度较轻,可耐受。结论对于晚期胰腺癌患者,化疗联合热疗临床优势明显,逆转了耐药性,近期疗效高,能改善患者生存质量。

Objective To explore the synergistic effectiveness of hyperthermia and GP（Gemcitabine and Cisplatin） in the treatment of patients with advanced pancreatic cancer.Methods 38 patients with advanced pancreatic cancer were treated by chemotherapy and local hyperthermia.All the patients had progressed disease after first line chemotherapy with Karnofsky performance status（KPS） of 60-70 and adequate organ function.The patients were treated by gemcitabine and cisplatine,and on day 2,5,and 9 during the chemotherapy,local radiofrequency hyperthermia was given at 41℃-43℃ for 60 minutes in tumor area.Results The response rate was 78.95%.The common side effects included gastrointestinal toxicities and myelosuppression（leukocyte reduction and thrombocytopenia）,but these side effects were all mild.Conclusion The local radiofrequency hyperthermia combined with GP is an effective regimen for treatment of advanced pancreatic cancer previously treated with chemotherapy.The regimen could enhance the response rate,improve patients＇quality of life,and reverse drug tolerance with significantly fewer side effects for advanced pancreatic cancer patients.