1,3-二甲基-5-甲氧基-2,3-二氢-2-氧-1H-吲哚-3-丙烯酸甲酯的制备

Preparation of Methyl 1,3-Dimethyl-5-methoxy-2,3-dihydro-2-oxy-1H-indole-3-acrylate

1,3-二甲基-5-甲氧基-2,3-二氢-2-氧-1H-吲哚-3-丙烯酸甲酯（1）可在Pd/C催化下加氢还原碳-碳双键,再经酯基水解成酸、Curtius重排及环合反应等转化为毒扁豆碱（physostigmine）和eserethole的合成前体。1的合成方法未见报道。

Methyl 1,3-dimethyl-5-methoxy-2,3-dihydro-2-oxy-1H-indole-3-acrylate was prepared by the addition-elimination reaction of 1,3-dimethyl-5-methoxy-2,3-dihydro-2-oxy-1H-indole and methyl 3-（1-imidazolyl）acrylate in the presence of n-BuLi in a yield of 90%.