南蛇藤化学成分研究

Studies on Chemical Constituents of Celastrus orbiculatus

采用柱色谱技术,从南蛇藤根茎95%乙醇浸膏的正丁醇部分分离得到8个苷类化合物,经MS和NMR分析,分别鉴定为3-羟甲基呋喃葡萄糖苷(1),大黄素-6-O-β-D-葡萄糖苷(2),3,4,5-三甲氧基苯酚葡萄糖苷(3),丁香酸葡萄糖苷(4),(1S,2S,4R)-1,8-反式桉叶素-2-O-(6-O-α-L-鼠李糖基)-β-D-葡萄糖苷(5),pumilaside A(6),3,4-二甲氧基苯酚-(6-O-α-L-鼠李糖基)-β-D-葡萄糖苷(7),3,4,5-三甲氧基苯酚-(6-O-α-L-鼠李糖基)-β-D-葡萄糖苷(8)。化合物1、2、4、5、6、7和8为首次从南蛇藤中得到,其中化合物2为首次从南蛇藤属植物中报道的蒽醌类化合物。

Column chromatographic technique was used for the isolation and purification of the chemical constituents of the n-butanol portion from 95% ethanol extract of the root and radix of Celastrus orbiculatus.Eight compounds were isolated and identified by means of MS and NMR spectroscopy as 3-furanmethanol β-D-glucopyranoside（1）,emodin-6-O-β-D-glucopyranoside（2）,3,4,5-trimethoxyphenyl-β-D-glucopyranoside（3）,glucosyringic acid（4）,（1S,2S,4R）-trans-1,8-cineole-2-O-（6-O-α-L-Rha）-β-D-glucopyranoside（5）,pumilaside A（6）,1-（α-L-rham（1→6）-β-D-glu）-3,4-dimethoxybenzenephenol（7）,1-（α-L-rham（1→6）-β-D-glu）-3,4,5-trimethoxyphenol（8）.Among them,compounds 1,2,4,5,6,7 and 8 were first isolated from this plant,and compound 2 was a constituent of anthraquinone first discovered from the Celastrus genus.