期刊文献+

咪唑-1-乙酸合成研究进展 被引量:3

Research Progress in the Synthesis of Imidazol-1-yl-acetic Acid
下载PDF
导出
摘要 咪唑-1-乙酸是制备唑来膦酸重要中间体,主要综述报道了咪唑-1-乙酸合成研究进展。 Imidazol-1-yl-acetic acid was the important intermediate of preparing zoledronic acid.The research progress in the synthesis of imidazol-1-yl-acetic acid was reported in the paper.
出处 《河北化工》 2010年第11期17-19,共3页 Hebei Chemical Industry
基金 河北省教育厅科学研究课题(Z2008478) 石家庄学院博士基金(2008) 石家庄学院科研启动基金立项项目(09YB001)
关键词 咪唑-1-乙酸 唑来膦酸 中间体 合成 imidazol-1-yl-acetic acid zoledronic acid intermediate synthesis
  • 相关文献

参考文献13

  • 1董华青,高建荣,贾建洪,徐时良.异环型双膦酸类药物唑来膦酸合成新工艺研究[J].浙江工业大学学报,2008,36(2):141-143. 被引量:6
  • 2Widler L,Jaeggi K A,Glatt M et al.Highly potent geminal bisphosphonates from pamidronate disodium(aredia)to zoledronic acid (zometa)[J].J Med Chem,2002,45(17):3 721-3 73B.
  • 3Kieczykowsk G R,Jobson R B,Melillo D G,et al.Preparation of(4-amino-l-hydroxybutylidene) bisphosphonicacid sodium salt MK-217(Alendronate Sodium)an improved procedure for the preparation of l-hydroxy-1,l-bisph-osphonic acids[J].J Org.Chem,1995,60(25):8 310-8 312.
  • 4Jaeggi K A,Widler L Substituted alkanediphosphonic acids and pharmaceutical use[P].US:4 393 130,1990.
  • 5Zaderenko P.Soledad Gil M,Ballesteros P.Synthesis and regioselective hydrolysis of 2-imidazol-1-ylsuccinic esters[J].J Org Chem 1994,59(21):6 268-6 273.
  • 6Patel V M.Chitturi T R.Thennati R A Process for the preparation of 2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid[P].WO:066 188,2005.
  • 7Singh S K,Manne N.Ray P C et al.Synthesis of imidazol-1-yl-acetic acid hydrochloride:A key intermediate for zoledronic acid[J].Beilstein Journal of Organic Chemistry,2008,4(42):1-4Pulla Reddy M,USHA Rani V,Venkaiah Chowdary N An.
  • 8improved process for the preparatin of zoledronic acid[P].W0:063 717,2005.
  • 9李家明,童元峰,张永.高血钙症治疗药唑来膦酸的合成方法改进[J].中国药物化学杂志,2002,12(3):164-165. 被引量:11
  • 10王洪勇,罗世能,刘晓亚,何拥军.四丁基碘化铵催化合成1H-咪唑-1-乙酸[J].精细化工,2004,21(z1):118-120. 被引量:2

二级参考文献30

  • 1王磊,孙兴华.KF-Al_2O_3催化咪唑的N-烷基化反应[J].化学通报,1993(10):38-39. 被引量:9
  • 2王洪勇,罗世能,刘晓亚,谢敏浩,何拥军.唑来膦酸的合成方法改进[J].江南大学学报(自然科学版),2004,3(6):611-613. 被引量:5
  • 3蒋晔,张晓青,徐智儒.唑来膦酸的合成[J].华西药学杂志,2005,20(1):29-30. 被引量:8
  • 4Perry C M, Figgitt D P. Zoledronic acid:a review of its use in patients with advanced cancer [J]. Drugs,2004,64(11):1197-1211.
  • 5Aronhime, Judith, Lifshitz L, et al. Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation [P]. US: 7,435,827.
  • 6[1]Jeanette W,Karine B,Stephan R,et al.Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid[J].J Pharmacol Exp Ther,2002,302:1055-1061.
  • 7[2]Kamijo T,Yamamoto R,Harada H,et al.An improved and convenient procedure for the synthesis of 1-substituted imidazoles[J].Chem Pharm Bull,1983,31(4):1213-1221.
  • 8[4]Zaderenko P,Gil MS,Balleteros P.Synthesis and regioselectivehydrolysis of 2-imidazol-1-ylsuccinic esters[J].J Org Chem,1994,59(21):6268-6273.
  • 9[6]Birkofer L,Richter P,Ritter A.Aktivierung"N-haltiger Heterocyclen durch Silyierung"[J].Chem Ber,1960,93:2804-2809.
  • 10Gil S, Zaderenzo P, Cruz F, et al. Imidazol-1-ylalkanoic acids as extrinsic ~HNMR probes for the determination of intracellular pH, extracellular pH and cellvolume[J]. Bioorg Med Chem ,1994,2(5) :305-314.

共引文献25

同被引文献10

引证文献3

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部