摘要
目的检测MMP-2、PTEN在食管鳞癌组织中的表达,探讨其与患者临床病理特征及其相关关系。方法采用免疫组化S-P法检测MMP-2、PTEN在40例食管鳞癌和20例正常食管上皮组织中的表达。结果 (1)食管鳞癌组织MMP-2、PTEN表达阳性率分别为80.00%、50.00%,与正常食管上皮组织比较差异均有统计学意义(P<0.01)。(2)MMP-2、PTEN阳性率在食管癌不同浸润深度、淋巴结有无转移和不同临床分期中均有统计学意义(P<0.05)。(3)PTEN与MMP-2、阳性率呈负相关(P<0.05)。结论食管鳞癌组织中MMP-2高表达,PTEN低表达,两者联合检测可能对食管鳞癌浸润转移的预后判断有一定指导意义。
Objective To detect the expression of MMP-2,PTEN and discuss their relationship in esophageal squamous cell carcinoma.Methods S-P immunohistochemical method was performed to detect expressions of MMP-2 and PTEN in 40 cases of esophageal squamous cell carcinoma and 20 normal subjects.Results The positive rate of MMP-2 and PTEN in esophageal squamous cell carcinoma patients was 80.00% and 50.00%,comparing with normal subjects,there were all significant differences（P〈0.01）;The positive rates of MMP-2 and PTEN were significantly correlated with invasion,clinical stage,lymph node metastasis（P〈0.05）;There were significantly negative correlations between PTEN and MMP-2（P〈0.05）.Conclusion Expression of MMP-2 is increased and PTEN is decreased in esophageal squamous cell carcinoma,they are correlated with clinical stage.They can be used as molecular biological markers for evaluating invasion and metastasis.
出处
《宁夏医学杂志》
CAS
2010年第11期980-982,F0002,共4页
Ningxia Medical Journal
基金
宁夏卫生厅重点科研计划课题(W2006477)
