摘要
研究地奥心血康对高脂血症大鼠血脂及脂蛋白的影响。用高脂饲料喂服雄性wistar大鼠,复制高脂血症大鼠模型。动物分5组:1、正常对照组:给予基础饲料+生理盐水。2、高脂模型组:高脂饲料+生理盐水。3-4、地奥心血康010、020g/kg组:高脂饲料+地奥心血康;5、阳性药肌醇烟酸酯组:高脂饲料+肌醇烟酸酯(01g/kg),连续灌胃给药10d后采血,测定血清甘油三脂(TG),总胆固醇(TC),高密度脂蛋白(HDL-C),计算低密度脂蛋白(LDL-C)。地奥心血康020、010g/kg均能明显降低高脂血症大鼠TC、TG、LDL-C(P<005P<001(与高脂模型组比),分别使TC降低30%、19%;TC降低45%、20%;使LDL-C降低57%、31%;020g/kg也能升高HDL-C,为12%。地奥心血康能降低高脂血症大鼠TC、TG。
To study the effects of Di-ao-xin-xue-kang(DAXXK)on blood lipids and Lipoprotein in hyperlipidemia rats.METHODS Feeding high-lipid diet to Wister rats to induce hyperlipidemia model.Total serum cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C)content and low density lipoprotein(LDL-C)content were measured.RESULTS TC,TG and LDL-C in hyperlipidemia rats were significantly reduced by DAXXK(P〈0 05 or P〈0 01,compared with hyperlipidemia rat model)in both 0 20 and 0 10g/kg DAXXK treated groups.TC was reduced by 30% and 19%;TG 45% and 20%;LDL-C 57% and 31%,respectively.On the other hand,DAXXK(0 20g/kg)treated groups increased HDL-C by 12%.CONCLUSIONS DAXXK could reduce TC,TG,LDL-C levels but increase HDL-C levels in hyperlipidemia rats.
出处
《川北医学院学报》
CAS
1999年第1期10-12,共3页
Journal of North Sichuan Medical College
关键词
高脂血症
脂蛋白
地奥心血康
Di-ao-xin-xue-kang,hperlipidemia,lipoprotein,rat