地奥心血康对高脂血症大鼠血脂及脂蛋白的影响

Effcts of Di-ao-xin-xue- kang on blood lipids and lipoprotein in hyperlipidema rats

研究地奥心血康对高脂血症大鼠血脂及脂蛋白的影响。用高脂饲料喂服雄性ｗｉｓｔａｒ大鼠，复制高脂血症大鼠模型。动物分５组：１、正常对照组：给予基础饲料＋生理盐水。２、高脂模型组：高脂饲料＋生理盐水。３－４、地奥心血康０１０、０２０ｇ／ｋｇ组：高脂饲料＋地奥心血康；５、阳性药肌醇烟酸酯组：高脂饲料＋肌醇烟酸酯（０１ｇ／ｋｇ），连续灌胃给药１０ｄ后采血，测定血清甘油三脂（ＴＧ），总胆固醇（ＴＣ），高密度脂蛋白（ＨＤＬ－Ｃ），计算低密度脂蛋白（ＬＤＬ－Ｃ）。地奥心血康０２０、０１０ｇ／ｋｇ均能明显降低高脂血症大鼠ＴＣ、ＴＧ、ＬＤＬ－Ｃ（Ｐ＜００５Ｐ＜００１（与高脂模型组比），分别使ＴＣ降低３０％、１９％；ＴＣ降低４５％、２０％；使ＬＤＬ－Ｃ降低５７％、３１％；０２０ｇ／ｋｇ也能升高ＨＤＬ－Ｃ，为１２％。地奥心血康能降低高脂血症大鼠ＴＣ、ＴＧ。

To study the effects of Di-ao-xin-xue-kang(DAXXK)on blood lipids and Lipoprotein in hyperlipidemia rats.METHODS Feeding high-lipid diet to Wister rats to induce hyperlipidemia model.Total serum cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C)content and low density lipoprotein(LDL-C)content were measured.RESULTS TC,TG and LDL-C in hyperlipidemia rats were significantly reduced by DAXXK(P〈0 05 or P〈0 01,compared with hyperlipidemia rat model)in both 0 20 and 0 10g/kg DAXXK treated groups.TC was reduced by 30% and 19%;TG 45% and 20%;LDL-C 57% and 31%,respectively.On the other hand,DAXXK(0 20g/kg)treated groups increased HDL-C by 12%.CONCLUSIONS DAXXK could reduce TC,TG,LDL-C levels but increase HDL-C levels in hyperlipidemia rats.