慢性肺心病脂质过氧化物一氧化氮内源性纤溶酶原激活物及其抑制剂的变化

The changes of lipid peroxide,nitric wxide and endogenous fibrinolysis in chronic cor pulmonale

为了探讨脂质过氧化物、一氧化氮、纤溶系统与慢性肺心病肺动脉高压形成的关系，对３２例急性加重期和４０例缓解期肺心病患者血清丙二醛（ＭＤＡ）、超氧化物歧化酶（ＳＯＤ）、一氧化氮（ＮＯ）、血浆组织型纤溶酶原激活物（ｔ－ＰＡ）及ｔ—ＰＡ抑制剂（ＰＡＩ）含量进行测定，并与４２例正常人作对比研究。结果提示急性期肺心病患者血清ＭＤＡ、血浆ＰＡＩ显著高于肺心病缓解期患者及正常人，而急性期肺心病患者血清ＳＯＤ、ＮＯ、血浆ｔ—ＰＡ显著低于肺心病缓解期患者及正常人，差异均具显著性（Ｐ＜００１）；缓解期肺心病患者血清ＭＤＡ、血浆ＰＡＩ高于正常人，而血清ＳＯＤ、ＮＯ、血浆ｔ—ＰＡ低于正常人，但差异不具显著性（Ｐ＞００５）。总之，脂质过氧化、一氧化氮含量减少。

To investigate the role of lipid peroxide,nitric oxide and endogenous fibrinolysis in the pathogenesis of pulmonary hypertension accompanied with pulmonary heart disease,the levels of serum malonic dyadic aldehyde(MDA),serum superoxide dismutase(SOD),serum nitric oxide(NO),plasma tissue plasminogen activator(t PA)and plasma t PA inhibitor(PAI) were determined in 32 patients with chronic cor pulmonale (CCP) in acute exaccerbating stage and in 40 cases with CCP in recovdry stage and in 42 control The levels of serum MDA and plasma PAI were significantly increased (P<0 01) but the levels ofserum SOD,NO and plasma t PA were decreased (P<0 01) in CCP in acute exaerbating stage as compared with CCP in recovery stage and healthy subjects.The levels of serum MDA and plasma PAI were higher,but the levels of serum SOD, NO and plasma t PA were lower in CCP in recovery stage than in control but the difference was not significant. The results suggest that lipid superoxide,decreased NO.and disturbanced fibrinolysis system are related to the modulation and exacerbation of pulmonary hypertension in pulmonary heart disease.