I期非小细胞肺癌的预后因素分析

Study of prognostic factors in patients with stage Ⅰ non-small cell lung cancer

目的 探讨分析影响Ⅰ期非小细胞肺癌患者术后远期生存率的因素.方法 回顾分析了北京胸科医院胸外科自1999年9月至2004年9月间手术治疗224例Ⅰ期非小细胞肺癌患者,分别对患者的性别、年龄、肿瘤分期、病理类型、分化程度、手术方式和是否术后辅助化疗共7个可能影响术后远期生存率的因素进行了单因素和多因素分析.结果 Ⅰa期和Ⅰb期非小细胞肺癌患者术后的5年生存率差异有统计学意义,单因素分析显示肿瘤分期、分化程度对非小细胞肺癌患者术后的5年生存率影响差异有统计学意义.而多因素分析同样表明肿瘤分期、分化程度是独立预后因素.结论 Ⅰa期和Ⅰb期非小细胞肺癌患者术后的5年生存率差异有统计学意义,肿瘤分期、分化程度是影响Ⅰ期非小细胞肺癌患者术后远期生存率的独立预后因素.

Objective To analyze the prognostic factors for patients with stage Ⅰ non-small cell lung cancer.Methods A total of 224 patients with stage Ⅰ non-small cell lung cancer operated from 1999 to 2004 were retrospectively reviewed.The clinical profiles of age, gender, T grade, type of resection, tumor pathological typing, tumor cell differentiation and post-operative chemotherapy were analyzed by SPSS 13.0 statistic software.Results The five-year survival of stages Ⅰa and Ⅰb non-small cell lung cancer were 78.7% and 51.5% respectively.In univariate analysis, T grade and tumor cell differentiation were independent prognostic factors respectively.In multivariate analysis, T grade and tumor cell differentiation were independent prognostic factors for overall survival.Conclusion There are significant differences in the five-year survival of stages Ⅰa and Ⅰb non-small lung cancer.Both tumor stage and tumor cell differentiation were independent prognostic factor for overall survival.