PLGA微粒/纳米粒基因载体的研究进展

Advance in the study of poly(lactide-co-glycolide) nano/microparticles as gene vector

生物可降解聚合物乳酸-羟基乙酸共聚物(PLGA)微米粒/纳米粒是一种新型的非病毒基因载体,由于其具有安全、无免疫原性、制备容易和装载容量大等优点而引起越来越多的关注和研究,特别是在质粒DNA(plasmid DNA,pDNA)传递方面具有巨大的研究空间和潜在应用价值。本文依据PLGA微米粒/纳米粒在基因载体中的研究现状,重点综述了载体的制备工艺和表面修饰方法及其在基因治疗和基因疫苗传递等方面的应用研究进展。

Biodegradable nano/microparticles of poly（D, L-lactide-co-glycolide） （PLGA） is a novel non-viral gene vector, which has many advantages, such as safety, non-immunogenicity, easy of large-scale preparation and well load-capability. Therefore, more and more attentions and researches have been paid on its application. Especially, PLGA has shown enormous potential application value and space in the field of plasmid DNA （pDNA） delivery system. On the basis of the current situation of PLGA nano/microparticles for pDNA delivery, this paper focused on summarizing the current preparation approaches and surface modified methods of PLGA particle, furthermore showing its application in gene therapy and genetic vaccine delivery. These showed that PLGA nano/microparticles have extensive prospect in the development of controlled gene delivery system.