臭氧治疗对破裂型腰椎间盘突出症患者自身体液免疫的影响

Application of ozone on autoimmunity of patients with lumbar prolapsed disc

目的:探讨医用臭氧对破裂型腰椎间盘突出症(LDH)患者自身体液免疫水平的影响。方法:选取50例破裂型LDH患者及50例健康成年人作为研究对象,比较两组血清中免疫球蛋白G(IgG)和M(IgM)含量,并应用医用臭氧微创治疗LDH患者,观察血清中IgG和IgM含量在治疗前后的变化。结果:破裂型LDH患者血清中IgG、IgM含量分别为16.04±2.58g/L及1.79±0.45g/L,较健康成年人的13.33±2.67g/L、0.89±0.34g/L均有显著升高(P<0.01);经医用臭氧治疗3d后患者的IgG、IgM含量分别降至14.15±2.43g/L及1.43±0.39g/L,均较治疗前明显降低(P<0.01)。结论:医用臭氧能够在一定程度上抑制破裂型LDH患者的自身体液免疫水平,这可能是其治疗腰椎间盘突出症的作用机制之一。

Objective：To investigate the use of ozone on autoimmunity of patients with lumbar prolapsed disc.Method：50 cases with lumbar prolapsed disc and 50 healthy adults were collected.The concentration levels of immunoglobulin G and M in peripheral blood by immunoturbidimetry between patients and healthy ones were compared,then lumbar disc herniation（LDH） patients underwent percutaneous intradiscal ozone-injection （PIOI）,and the concentration levels of immunoglobulin G and M of these patients between pre-operation and post-operation were compared.Result：The immunoglobulin G and M level in peripheral blood of LDH patients were 16.04 ±2.58g/L and 1.79 ±0.45g/L respectively.Both were significantly higher than that of the healthy adults （13.33±2.67g/L and 0.89±0.34g/L）（P0.01）.After operation,the levels were 14.15±2.43g/L and 1.43± 0.39g/L for immunoglobulin G and M level respectively,both were significantly lower than those of preoperation （P0.01）.Conclusion：Ozone for medical use can inhibit the auotoimmunity of patients with lumbar prolapsed disc,which remains one of the mechanisms for managing LDH.