激活素-抑制素-卵泡抑素系统与子宫内膜异位症所致排卵障碍的关系

Relationship between activin-inhibin-follistatin system and ovulation failure and its significance in endometriosis

激活素、抑制素和卵泡抑素是细胞转化生长因子β超家族的成员,可以通过多方面多层次调控卵泡的生长发育,其既能负反馈调节下丘脑-垂体-卵巢轴,又能参与卵巢内局部信号微调节。排卵障碍指不能产生正常的卵子,是女性不育的第二位原因。子宫内膜异位症患者因卵泡发育微环境改变可导致排卵障碍。本综述通过对激活素-抑制素-卵泡抑素与卵泡发育及在子宫内膜异位症患者体内的变化情况,探讨该系统与子宫内膜异位症患者所致排卵障碍的关系。

Activins, inhibins and follistatin are the members of the transforming growth factor-β （TGF-β） superfamily, and they can regulate follicle development through both negative feed-back effect on hypothalamus-pituitary-ovarian axis and coordination with intra-ovarian signals. Ovulation failure, the failure of production of normal mature eggs, is the second most common cause of female infertility. The changes of ovarian follicular microenvironment may lead to ovulation failure in endometriosis patients. Therefore we reviewed the changes of aetivin-inhibin-follistatin system in the endometriosis patients in order to evaluate the relationship between the activin-inhibin-follistatin and ovulation failure.