富含丙氨酸的豆蔻酰化蛋白酶C与阿尔茨海默病

Myristoylated Alanine-rich C Kinase Substrate in Alzheimer's Disease

富含丙氨酸的豆蔻酰化蛋白激酶C的作用底物(myristoylated alanine-rich C kinasesubstrate,MARCKS)作为蛋白激酶C(protein kinase C,PKC)的重要底物,主要存在于大脑神经元的树突棘,介导着神经元表面信号与肌动蛋白的运动,与树突棘可塑性密切相关。阿尔茨海默病(Alzheimer's disease,AD)患者脑组织PKC明显不足,MARCKS的磷酸化异常,这些病理表现都在AD产生痴呆症状的过程中发挥作用。故本文将对MARCKS在学习记忆功能中的作用以及AD状态下的变化进行综述。

myristoylated alanine-rich C kinase substrate（MARCKS） has been suggested to be located in neuron dendritic spines,as the major substrate for protein kinase C（PKC）.It mediates the neuron surface signal and actin cytoskeleton,which is closely related with dendritic spines plasticity.The brain of Alzheimer＇s disease has significant PKC deficiency and abnormal MARCKS phosphorylation,which are both important for dementia symptom of AD.So,the role of MARCKS and its alteration in learning and memory function of AD will be reviewed in this article.