诱导性多潜能干细胞的研究进展

Research Progress of Induced Pluripotent Stem Cells

作为生命科学界一大热点领域的干细胞研究一直备受关注,而诱导性多潜能干细胞(induced pluripotent stem cells,简称iPSC或iPS细胞)的产生具有里程碑的意义。从2006、2007年日本美国科学家先后发表对小鼠与人诱导性多潜能干细胞的研究成果至今,短短三年时间,iPS细胞的研究领域以惊人的速度和影响范围发展,又有了很多新的进展与突破,并荣登2007年NatureScience times年度十大科学成果突破榜及2008年Science年度十大科学成果突破榜榜首。本文概述了诱导性多潜能干细胞的研究背景、研究方法和进展、在哺乳动物中的研究范围和应用现状,最后提出了展望和有待解决的问题,以期为诱导性多潜能干细胞研究者进行更深入的研究提供一定的借鉴。

The recent success on induced pluripotent stem cells（iPSC,iPS Cells） is a significant landmark for Stem Cells research,which has been a hot topic in life science field.Japanese and American scientists successfully established mouse and human iPS cell lines in 2006 and 2007 respectively and only three years later,iPS cells research has been developed at tremendous rapid and numerous relative improvements and breakthroughs have been achieved in both of basic and application fields.iPS cells ranked number 1 of top 10 science stories in Nature Science times（2007） and Science（2008）.This review summarizes the background of iPS cells research,the different strategies used to generate iPS cells and their developments,application status on mammals and the prospects and problems of current iPS cells techniques.This review might be helpful for related scientists to further investigate iPS cells.