G蛋白信号调节蛋白5在肿瘤血管正常化中的作用

Regulator of G-protein signaling 5 normalizes tumor vessels

G蛋白配对的生理过程需要微调附属分子如G蛋白信号调节蛋白(regulator of G-protein signaling,RGS)。作为肿瘤血管周细胞的标记物,RGS5最近已被确定在致癌的血管成熟和血管再造过程中起中枢作用。值得注意的是,缺乏RGS5肿瘤的血管形态标准化且血流丰富。同时,发现肿瘤血管的形态变化也导致淋巴细胞功能的改善和抗肿瘤免疫疗法的成功。因此,研究RGS5与肿瘤血管形态学的关系,可增强对血管再造的理解,促进抗癌治疗的改善。

G-protein-coupled biological processes are important for an ever-increasing number of human diseases and require fine-tuning through accessory molecules such as the regulators of G-protein signaling（RGS）.RGS5,a marker for tumor-resident pericytes,was recently established as playing a pivotal role in vascular maturation and vessel remodeling during carcinogenesis.Remarkably,tumors arising in a RGS5-deficient background display vessels with normalized morphology and an overall improved blood flow.Furthermore,these morphologic changes also lead to dramatic improvements in lymphocyte access to tumors and success of antitumor immunotherapy.Here,we consider the implications of these findings,and how they contribute to enhancing our understanding of remodeling angiogenic vessels as means for improving anticancer therapies.