肋骨骨折合并血气胸患者体液免疫水平变化的临床观察

Clinical Study on Immune Function of Rib Fracture combined With Hemopneumothorax

目的:观察肋骨骨折合并血气胸患者体液免疫的变化情况。方法:58例肋骨骨折合并血气胸患者为观察组,受伤后1、7、14d检测免疫球蛋白IgA、IgG、IgM、补体C3、C4、C反应蛋白(CRP)水平,以45例较轻胸外伤作对照组。结果:肋骨骨折合并血气胸患者在受伤后1d,免疫球蛋白及补体明显下降,CRP明显升高,与轻伤对照组比较差异有统计学意义(P<0.05);伤后7d上述指标逐渐恢复,7d和14d数值与轻伤对照组比较差异无统计学意义(P>0.05)。结论:肋骨骨折合并血气胸患者体液免疫抑制,机体易感性增加,在常规治疗的同时,早期进行及时有效的干预,提高免疫功能,有可能促进康复,减少并发症发生。

Objective：To study the influence of rib fracture combined with hemopneumothorax on immune function. Methods：Serum immunoglobulin IgA, IgG, IgM, complement C3, C4 and C-reactive protein （CRP） level in 58 patients of rib fracture complicate with hemopneumothorax were assayed on the 1st, 7th and 14th day after injury respectively. The levels of the above parameters in another 45 patients with minor chest injury were used as control.Results：The levels of serum immunoglobulins and complements in the patients of rib fracture combined with hemopneumothorax were significantly lower, while the level of serum CRP was significantly higher than the patients of control group on the 1st day after injury （P0.05）. The above indexes of the 7th day restored gradually, and the levels of the 7th and 14th day after injury were insignificantly different compared with the control group （P0.05）.Conclusion：The suppression of humoral immune function in patients with rib fracture and hemopneumothorax can causes increase of susceptibility. Timely and effective intervention aiming at improving immune function can promote recovery process and reduce complications.