血清甘胆酸水平对肝硬化及原发性肝癌诊断价值的研究

Study on the diagnostic value of serum glycocholic acid level for hepatic cirrhosis and primary hepatocelluar carcinoma

目的：探讨血清甘胆酸对肝硬化及原发性肝癌诊断的价值。方法：选择５８例肝炎后肝硬化，１８例原发性肝癌和２６例无肝胆病史的对照组，用放免法测定血清甘胆酸（ＣＧ）含量。结果：肝硬化和肝癌组血清ＣＧ明显高于对照组，随肝硬化肝功能受损程度加重，ＣＧ逐渐增高（Ｃ＞Ｂ＞Ａ级），而肝硬化和肝癌组ＣＧ无明显差异。肝硬化组ＡＬＴ与ＣＧ比较，肝癌组ＣＧ与ＡＦＰ比较，ＣＧ均明显较ＡＬＴ及ＡＦＰ更为敏感，阳性率更高。结论：ＣＧ是反应肝细胞损伤及肝病严重程度的敏感指标，对判断肝硬化的预后及原发性肝癌的诊断具有重要的参考价值。

Objective:To investigate the value of serum CG in diagnosing liver cirrhosis (L.C) and primary hepatocellular carcinoma (PHC).Mothods:By using RIA method,the serum contents of CG were detected from 58 LC,18 PHC patients and 26 controls.Results:The serum levets of CG in LC and PHC groups were much higher than those in controls.With the exacerbation of the hopatic function injured,CG lwels were graduately in creased (C>B>A class),but there was no significance difference between LC and PHC groups.CG was much more sensitive than ALT in LC group and AFP in PHC group,and its positive rate was much higher.Conclusions:CG was a sensitive indicator,reacting the exent of hepatocytes injured and liver disease devoloping. CG was also of help for the assessent of the prognosis of LC and the diagnosis of PHC.