SNCG、nm23在胃癌中的表达及临床意义

Expression of SNCG and nm23 in gastric carcinoma and their clinical significance

目的:研究胃癌中SNCG,nm23的表达及其临床意义,并进一步探讨它们在胃癌中表达的相关性。方法:采用免疫组化法观察60例胃癌及20例胃正常黏膜石蜡标本中SNCG、nm23的表达情况,实验数据用SPSS12.0软件包进行统计。结果:在胃癌中SNCG蛋白阳性率65%,高于周围正常组织(P<0.05)。nm23在胃癌组织中表达阳性率为55%,低于周围正常组织(P<0.01)。SNCG、nm23的表达与肿瘤浸润深度、淋巴结转移及肿瘤临床分期均相关(P<0.05)。SNCG与nm23在胃癌中的表达呈负相关(P<0.05))。结论:SNCG、nm23蛋白的表达与胃癌发生、发展和浸润转移相关。胃癌组织中SNCG的表达与nm23的表达呈负相关,二者的检测有助于胃癌浸润转移的预测,对判断患者预后有重要参考价值。

Objective：To study the expression of SNCG and nm23,their clinical significance and their relation in gastric carcinoma.Methods： Immunohistochemical ABC technique was used to examine the expression of SNCG and nm23 in gastric carcinom and normal gastric mucosa.Results： The positive rates of SNCG and nm23 in gastric carcinoma were 65% and 55%,but the rates in the normal gastric mucosa were 0% and 100%.The expression of SNCG and nm23 was correlate with invasion,metastasis of lymph node,clinical stage in gastric carcinoma.There was negative correlation between them.Conclusion： The expression of SNCG and nm23 plays an important role in the development,invasion and metastasis of gastric carcinom.To detect them may help the evaluation of invasion,metastasis and prognosis of gastric carcinom.