^(153)Sm-EDTMP放射治疗辐射对肿瘤骨转移患者血象的影响

Effects of ^(153)Sm-EDTMP radiotherapy radiation on the blood of carcinoma bone metastases patient

目的:探讨利用放射性制剂153Sm-EDTMP(153钐-乙二铵四甲基磷酸)对肿瘤骨转移疼痛患者进行治疗时,辐射对患者血象的影响。方法:利用全自动血液分析仪,对93例肿瘤骨转移疼痛患者153Sm-EDT-MP治疗前、治疗后1天、7天及1个月血象(包括红细胞、白细胞、血红蛋白、血小板等系列)进行检测并分析研究。结果:153Sm-EDTMP治疗后1天白细胞、粒细胞升高,淋巴细胞降低(P<0.05);治疗后7天白细胞、粒细胞、淋巴细胞、红细胞、血红蛋白测定及血小板计数均低于治疗前(P<0.05);治疗后1个月红细胞计数升高(P<0.05)。结论:利用153Sm-EDTMP治疗肿瘤骨转移疼痛时,辐射对患者血象有一定影响,但影响较轻微且为一过性,随时间推移,血象各项指标均可恢复正常。

Objective：To evaluate the effects of 153Sm-EDTMP radiotherapy radiation on the blood of carcinoma bone metastases patient.Methods：The level of blood（included red blood cell,white blood cell leukocyte,hemoglobin and platelet series） were measured by full automatic hemocyte analyzer in 93 cases of carcinoma bone metastases patient（before 153Sm-EDTMP radiotherapy,after 153Sm-EDTMP radiotherapy 1 day,7 days and 1 month）.The changes of blood level were compared with that before 153Sm-EDTMP radiotherapy.Results：The level of leukocyte,granulocyte increased,lymphocyte decreased（P0.05） after 153Sm-EDTMP radiotherapy 1 day.The level of leukocyte,granulocyte,lymphocyte,red blood cell,hemoglobin and platelet decreased（P0.05） after 153Sm-EDTMP radiotherapy 7 days.The level of red blood cell increased after 153Sm-EDTMP radiotherapy 1 month（P0.05）.Conclusion：Radiation of 153Sm-EDTMP radiotherapy on carcinoma bone metastases patients have influences on blood.The influence was light,the level of blood will be normal gradually.