嗅神经母细胞瘤临床诊断与治疗探讨

Diagnosis and treatment of esthesioneuroblastoma in the nasal cavity and sinuses

目的探讨鼻腔鼻窦嗅神经母细胞瘤的临床特点及诊断治疗方法。方法回顾性分析本院2000年1月至2006年12月收治7例嗅神经母细胞瘤患者临床表现、诊断和手术径路、预后。结果本组手术+放疗及化疗7例,2例1年内复发。复发病例经再次放疗及化疗,随访1年,1例死亡,1例带瘤生存。结论嗅神经母细胞瘤早期诊断困难。行鼻内窥镜下经额鼻联合径路切除是较理想的手术方式。术后联合放疗及化疗十分重要。

Objective To discuss the clinical characteristics, diagnosis and treatment of esthesioneuroblastoma （ENB）. Methods The clinical data of 7 patients with ENB were analyzed retrospectively, and the clinical characteristics, diagnosis, surgical approaches and prognosis of the disease were discussed. Results The 7 patients received surgical treatment combined with radiotherapy and chemotherapy. Tumor relapse occurred within one year in two cases, which were treated with a second operation combined with radiotherapy, and one patient died and one survived with tumor after a one-year follow-up. Conclusion Early diagnosis of ENB can be difficult. Transnasal-frontal approach with nasal endoscope is effective approach to ENB treatment, and the patients may benefit from postoperative radiotherapy and chemotherapy to improve the prognosis.