摘要
以大刺猴头（８８）多糖（ＨＥＰＳ）２００ｍｇ／ｋｇ提前经口给予小鼠，连续７天后，再合并给予小鼠环磷酰胺４０ｍｇ／ｋｇｉｐ连续２次，间隔２４小时。检测ＨＥＰＳ对环磷酰胺所致小鼠骨髓嗜多染红细胞微核率增加的影响。结果提示：ＨＥＰＳ可以拮抗环磷酰胺所致小鼠骨髓嗜多染红细胞微核率的增加，与阳性对照组比较有显著性差异（Ｐ＜０．０１）。以ＨＥＰＳ２００ｍｇ／ｋｇ提前经口给与小鼠，连续７天后，再合并给予小鼠环磷酰胺２０ｍｇ／ｋｇｉｐ连续５天。最终检测ＨＥＰＳ对环磷酰胺所致小鼠精子畸形率增加的影响。结果提示：ＨＥＰＳ可以拮抗环磷酰胺所致小鼠精子畸形率的增加，与阳性对照组比较有显著性差异（Ｐ＜０．０１）。
By means of PCE micronucleus test and sperm malformation test in mice,we found that HEPS,which was administered orally for consecutive 7 days at dose 200mg/kg,could significantly decrease the frepuencies of PCE micronucleus and sperm malformation compared with the cyclophosphamide group(WTBXP <0.05).The results of the experiments suggested that HEPS had certain antimutagenic effect.
出处
《山西临床医药》
1999年第2期157-159,共3页
Shanxi Clinical Medicine
关键词
大刺猴头
多糖
微核
抗突变
Hericium erinaceus polysaccharides (HEPS)
PCE micronucleus
Sperm malformation
Antimutagenic effect
