Wnt信号与神经干细胞分化

Wnt signaling and differentiation of neural stem cells

背景:研究表明,移植入宿主体内的神经干细胞可分化为神经元或神经胶质细胞。Wnt信号通路与神经干细胞的分化密切相关。通过调节Wnt信号通路可控制神经干细胞的定向分化。目的:对神经干细胞分化及其与Wnt信号通路的关系进行综述.方法:应用计算机检索2002-02/2010-03 Medline数据库、Ovid数据库、CNKI、EBSCO数据库与神经干细胞相关文献。检索词为"神经干细胞,神经再生,Wnt信号,神经元,分化"。纳入与神经干细胞分化及Wnt信号系统相关文献,排除重复性研究,保留30篇文献进行综述。结果与结论:神经干细胞是一类具有自我更新和多向分化潜能的细胞,能分化形成机体中枢神经系统几乎所有类型的细胞。Wnt信号通路在神经干细胞的分化中起重要作用。文章从神经干细胞、Wnt信号通路、Wnt信号通路与神经干细胞的分化等方面分别进行了叙述。然而,Wnt信号通路控制神经干细胞分化的具体机制还不是很清楚。

BACKGROUND：Studies have suggested that neural stem cells（NSCs） transplanted in the host can differentiate into neurons or glial cells.Wnt signaling pathway is closely associated with NSC differentiation.The oriented differentiation of NSCs can be controlled by regulating Wnt signaling pathway.OBJECTIVE：To summarize the relationship of NSC differentiation and Wnt signaling pathway.METHODS：A computer-based online search of Medline,Ovid,CNKI,and EBSCO databases was undertaken for the literatures of NSCs published from February 2002 to March 2010.The key words were ＂neural stem cells,neural regeneration,Wnt signaling,neuron,differentiation＂.The literatures associated with NSC differentiation and with Wnt signaling system were included,whereas repetitive studies were excluded.A total of 30 remaining literatures were used for review.RESULTS AND CONCLUSION：NSCs possess the potential of self-renewal and multi-directional differentiation,can differentiate into many types of cells in the central nervous system.Wnt signaling pathway plays an important role in NSC differentiation.This study analyzed NSCs,Wnt signaling pathway,the correlation of Wnt signaling pathway and NSC differentiation.However,precise mechanism of controlling NSC differentiation by Wnt signaling pathway remains unclear.