医用聚乳酸材料的改性及应用

Modification and application of medical poly(lactic acid) materials

背景:聚乳酸是一种具有良好的生物相容性和可生物降解性的脂肪族聚酯类高分子材料,目前国内外对聚乳酸的改性主要有化学改性、物理改性以及制成复合材料等几种改性方法。目的:综述聚乳酸的各种改性方法及应用研究进展,展望未来聚乳酸类材料的研究方向。方法:应用计算机检索Science Direct数据库、NSTL数据库系列和中国学术期刊全文数据库中1999-01/2010-03关于聚乳酸改性研究的文章,在标题和摘要中以"聚乳酸;改性;医学"或"PLA;Modification;Medical"为检索词进行检索。选择文章内容与聚乳酸改性相关,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到246篇文献,根据纳入标准选择43篇文章进行综述。结果与结论:对聚乳酸改性研究进展的了解,有利于更合理选择改性剂及改性方法,使聚乳酸的力学性能、热学性能等得到改善,以及降解周期可控。通过该方面改性研究进展的综述,能指导新产品开发和扩大聚乳酸材料在医药学领域的应用。

BACKGROUND： Poly（lactic acid） is an aliphatic polyester with good biocompatibility and biodegradability. The main modified methods of poly（lactic acid） are chemical modification, physical modification and composite materials. OBJECTIVE： To review the various modified methods and application research of poly（lactic acid）, to put forward research direction of poly（lactic acid） materials. METHODS： The Science Direct database, NSTL series database and full text database of Chinese Academic Journal from January 1999 to March 2010 were searched by computer for the articles of poly（lactic acid） modification, using ＂PLA, modification, medicine＂ in English and Chinese in title and summary as Key words. Articles related to poly（lactic acid） modification were selected, those published recently or in the authoritative magazine were preferred in the same field. Totally 246 articles were searched after primary screen, according to the inclusive criteria, 46 articles were involved in review. RESULTS AND CONCLUSION： Understanding of poly（lactic acid） modification is conducive to elect a more reasonable modifier and modified method, so that the mechanical and thermal properties of poly（lactic acid） are improved, and degradable cycle is controlled according to needs. Through the review of poly（lactic acid） modification, new product development and expanded application of poly（lactic acid） materials in medical field can be guided.