四种隆鼻材料在临床应用中的生物学性能比较

Biological properties of four kinds of nose augmentation materials in clinical application:A comparison study

目的:比较4种隆鼻材料的生物学特性,为临床医生选择理想的隆鼻材料提供依据。方法:电子检索万方数据库,发表于1999-01/2009-12的有关隆鼻材料的临床研究文献。排除重复研究、综述或Meta分析,对纳入的18篇文献进行隆鼻材料的生物学特性评价。结果:在鼻部整形的各种充填物中,自体软骨组织一直是最安全可靠的首选材料,但由于取材局限而未能广泛应用。膨体聚四氟乙烯是一种新型的较为理想的隆鼻材料,但因价格因素而不能为广大受术者接受,目前,固体硅橡胶仍是隆鼻术的主要材料。结论:理想的隆鼻材料应具备取材方便、无毒性、无致癌、无免疫源性、组织相容性好和不易变形等优点。目前应用广泛的固体硅橡胶、聚四氟乙烯、人工骨、自体软骨等4种隆鼻材料各有利弊,应根据不同患者的自身条件和经济情况,选择适合的隆鼻材料。

OBJECTIVE： To compare the biological characteristics of four kinds of nose augmentation materials, and to provide evidene for clinicians to select the ideal augmentation material. METHODS： A computer search of Wanfang database was performed for articles published from January 1999 to December 2009 about the clinical studies of nose augmentation materials. Repeated study, review or Meta analysis were excluded, 18 literatures were included to evaluate the biological properties of nose augmentation materials. RESULTS： Among a variety of fillings in nasal plastic surgery, autologous cartilage is the most safe and reliable material, but the source limitations restrict its widely application. Polytetrafluoroethylene is a new ideal material for nose augmentation, but it is not available by the majority of affected patients due to the price, at present, solid silicone rubber is still the main material for augmentation rhinoplasty. CONCLUSION： The ideal nose augmentation material should be easily obtained, non-toxic, non-carcinogenic, non-immunogenic, good biocompatible and not easily deformed. Now the widely used solid silicone rubber, polytetrafluoroethylene, autologous cartilage and other materials have advantages and disadvantages, we should select the appropriate augmentation material based on patient’s different conditions and economic situation.