不同糖耐量人群脉搏波传导速度的变化及相关因素分析

The study of pulse wave velocity and related factors in different glucose tolerance people

目的采用脉搏波传导速度评价不同糖耐量人群早期动脉硬化情况及其相关影响因素。方法选取糖耐量异常者30例,初诊2型糖尿病者30例,除外心脑血管疾病及其他疾病。另选取健康体检者30例作为对照组。分别测量身高、体重、血压,检测空腹、餐后血糖、血脂水平,并测定其脉搏波传导速度,比较三组人群各项指标差异,并分析其相关性。结果糖尿病及糖耐量异常人群均出现脉搏波传导速度异常;脉搏波传导速度与空腹、餐后血糖水平正相关。结论糖尿病前期人群及糖尿病早期即有血管内皮功能障碍存在,应予以早期干预。

Objective To evaluate early atherosclerosis（AS） by pulse wave velocity and to probe the related risk factor.Methods 90 subjects 〔30 cases with type 2 diabetes（T2DM）,30 cases with impaired glucose tolerance and 30 healthy people〕 aged from 35 to 45,without cardio-cerebral-vascular disease and other diseases,were chosen from April to October 2009.Height,weight,blood pressure of all the subjects were measured,and fasting plasma glucose （FPG）,postprandial blood glucose and lipid profile were tested.Then all the subjects accepted pulse wave velocity test.Results The abnormality of pulse wave velocity was found both in impaired glucose tolerance stage and early stage of T2DM.FPG and postprandial blood glucose were positive correlated with pulse wave velocity.Conclusions Endothelial dysfunction exits in impaired glucose tolerance people as well as in T2DM.Positive intervention should be taken to delay the progress of AS.