自体髂骨植骨及加或不加钢板内固定治疗脊柱结核60例：置入后C-反应蛋白水平与植骨融合时间的相关性(英文)

Autologous iliac bone graft combined with or without plate internal fixation for the treatment of spinal tuberculosis in 60 cases Correlation between postoperative C-reactive protein level and bone graft fusion time

背景:临床实践中观察到脊柱结核患者行结核病灶清除、植骨、加或不加钢板内固定术后患者的C-反应蛋白变化与植骨块骨性融合时间有一定的联系。目的:分析脊柱结核患者术后C-反应蛋白含量水平和植骨融合时间的相关性。方法:选择2007-01/2009-12脊柱结核患者60例,均行结核病灶清除、自体髂骨植骨、加或不加钢板内固定术,并经病理证实。术后1,7,14d检测C-反应蛋白水平,按C-反应蛋白平均值变化程度分4组:C-反应蛋白水平10～25mg/L为轻度升高组,26～50mg/L为中度升高组,51～100mg/L为高度升高组,>101mg/L为极度升高组。术后12,16,24周行X射线或CT检查及复查C-反应蛋白,记录植骨块骨性融合情况并记录融合时间。对4组脊柱结核患者术后C-反应蛋白水平和植骨块骨性融合时间进行差异性分析和相关性研究。结果与结论:轻度升高组18例,中度升高组21例,高度升高组13例,极度升高组8例;骨性愈合时间:≤12周8例,≤16周34例,≤24周18例。4组植骨块骨性融合时间差异性分析显示差异有非常显著性意义(χ2=13.990,P=0.003),Spearman相关分析显示,术后C-反应蛋白水平多样性与脊柱结核术后植骨块骨性融合时间正相关(r=0.420,P=0.001)。

BACKGROUND：Clinical practice showed that there are certain correlations between postoperative C-reactive protein levels and bone graft fusion time following focal debridement,autologous iliac bone graft,with or without plate internal fixation,for the treatment of spinal tuberculosis.OBJECTIVE：To analyze the correlation between postoperative C-reactive protein levels and bone graft fusion time of spinal tuberculosis patients.METHODS：A total of 60 cases with spinal tuberculosis were selected from January 2007 to December 2009.All patients were underwent focal debridement,autologous iliac bone graft,with or without plate internal fixation,and confirmed by pathology.The C-reactive protein levels were determined at 1,7 and 14 days after operation,and then,according to average changes of C-reactive protein levels,the cases were assigned into 4 groups：10-25 mg/L served as the mildly increase group,26-50 mg/L as the moderately increase group,51-100 mg/L as the highly increase group,and greater than 101 mg/L as the extremely increase group.Postoperative C-reactive protein levels were examined at 12,16,and 24 weeks after operation,the bone graft fusion was observed by X-ray or CT examination,in addition,bone block fusion time was recorded.All groups of patients with spinal tuberculosis postoperative C-reactive protein diversity and bone graft fusion time were analyzed by variability and correlation analysis.RESULTS AND CONCLUSION：There were 18 cases in the mildly increase group,21 cases in the moderately increase group,13 cases in the highly increase group,and 8 cases in the extremely increase group.The bone fusion time showed that：there were 8 cases equal to or less than 12 weeks,34 cases equal to or less than 16 weeks,and 18 cases equal to or less than 24 weeks.There were significant differences among 4 groups in bone graft fusion times（X2=13.990,P=0.003）.Spearman correlation analysis showed that,there was a positive correlation between postoperative C-reactive protein levels and bone fusion time（r=0.420,P=0.001）.