犬自身胆汁灌注胰管与急性胰腺炎病变程度的关系

THE EFFECTS OF AUTOLOGOUS BILE PERFUSION INTO DOG'S PANCREATIC DUCT ON THE SEVERITY OF INDUCED ACUTE PANCREATITIS

为探讨自身胆汁灌注胰管与急性胰腺炎时胰腺病理改变的关系，采用３０只本地健康成年杂种犬，随机分为５组，每组各６只，以不同压力、不同持续时间灌注犬胰管，观察胰腺的组织学变化。结果发现：胆汁灌注的压力越高，持续时间越长，越容易引起急性出血坏死性胰腺炎，而且坏死病变越重；相反，则主要引起急性水肿性胰腺炎。从而证明胆汁灌注的压力、持续时间及二因素的协同作用对急性胰腺炎严重程度有显著影响，早期减压可能有助于改善急性胰腺炎的预后。

To evaluate the effects of different pressure and duration of autologous bile perfusion into dog's pancreatic duct on the severity of induced acute pancreatitis. Thirty mongrel dogs were divided into five groups, with each group consisting of six dogs. Histological changes of pancreas were observed. Results: Histological changes of pancreas were correlated with the pressure and duration of autologous bile perfusion into pancreatic duct. It was easier to produce acute hemorrhagic necrotizing pancreatitis in the groups with a higher pressure and a longer duration of perfusion than in the groups with a lower pressure and a shorter duration. The results indicated that there was a significant effect of higher pressure and longer duration bile perfusion into pancreatic duct on the severity of induced acute pancreatitis.