成骨蛋白1在椎间盘退变和修复中的作用

Role of osteogenic protein-1 in disc degeneration and repair

背景:椎间盘的再生修复是当前骨科疾病治疗所面临的一个难题,而成骨蛋白1具有强大的骨诱导活性,能够在体内诱导骨和软骨形成。目的:总结并讨论成骨蛋白1在椎间盘退变和修复中的作用。方法:由第一作者用计算机检索中国期刊全文数据库(CNKI:1990/2010)和Pubmed数据库(1990/2010),检索词分别为"椎间盘,退变,成骨蛋白1/骨形态发生蛋白7"和"intervertebral disc,degeneration,osteogenic protein-1/bone morphogenic protein-7"语言分别设定为中文和英文。从体外和体内两方面对成骨蛋白1对椎间盘细胞及其退变的影响进行介绍。结果与结论:共检索到56篇文章,按纳入和排除标准对文献进行筛选,共纳入27篇文章。结果表明成骨蛋白1具有促进细胞合成蛋白多糖和胶原的作用,可调节和恢复椎间盘退变中细胞外的基质代谢,可有效延缓椎间盘退变。

BACKGROUND： How to regeneration and repair intervertebral discs puzzles doctors in orthopedics. With a strong osteoinductive activity, osteogenic protein-1 can induce bone and cartilage formation in vivo. OBJECTIVE： To summarize and discuss the effects of osteogenic protein-1 on disc degeneration and repair. METHODS： Databases of China Journal of Full-text Database （CNKI） and PubMed were searched by the first author using Key words of ＂intervertebral disc; degeneration; osteogenic protein-1/bone morphogenic protein-7＂ to find papers published between 1990 and 2010 both in Chinese or English. The effects of osteogenic protein-1 on intervertebral disc cells and its degeneration both in vitro and in vitro were introduced. RESULTS AND CONCLUSION： Totally 56 papers were retrieved by computer, and 27 documents were selected according to the inclusive and exclusive criteria. As a result, osteogenic protein-1 has an effect on promoting disc cells synthesizing collagen and proteoglycan, can adjust and restorate the metabolism of extracellular matrix in disc degeneration, and shows a bright future to retard disc degeneration.