肺癌患者血浆GST-π水平测定及其临床意义

Clinical significance of acid glutathione S tranceferase in patients with lung cancer

目的：探讨肺癌患者手术和化疗前后血浆ＧＳＴ－π水平的变化。方法：应用ＲＩＡ方法对３２例手术和２６例化疗的肺癌患者进行动态检测。结果：无论手术还是化疗前后患者血浆ＧＳＴ－π水平均明显高于正常对照组。手术后患者血浆ＧＳＴ－π水平明显低于手术前，但其与术前患者的病理类型、组织分化和ＴＮＭ分期等无明显相关。化疗前、后血浆ＧＳＴ－π水平无显著差异，化疗疗效与疗前血浆ＧＳＴ－π水平存在相关性，有效组疗前血浆ＧＳＴ－π水平明显低于无效组。结论：血浆ＧＳＴ－π水平与肿瘤负荷密切相关，对于监测手术效果可能有一定的帮助；另外血浆ＧＳＴ－π水平与肺癌化疗疗效密切相关。

Objective:To study the clinical significance on plasma glutathione S tranceferase (GST π) level in patients with lung cancer.Methods: The plasma levels of GST π were measured by RIA in 58 lung cancer patients and 139 healthy adults served as control. Results: The plasma GST π levels elevated above a cut off value of 13.35μg/L in 43 of the 58 patients (mean ± 1.96 standard deviations in 139 healthy control subjects). Plasma levels of GST π reduced greatly after operation. But no correlations were noted among GST π level, pathological type, histological differentiation and TNM stage ( P >0 05). And there were no significant differences for pre or post chemotherapy. The mean pretreatment GST π level was significantly lower in patients with a partial responce to chemotherapy than those with no response.Conclusion: The plasma GST π level may be a valuable tumor marker and may help to avaluate operation effect for lung cancer. Interestingly, pre treatment plams GST π level seems to be a useful indicator for predicting therapeutic response to combination chemotherapy regiments including platinum compound in lung cancer.