心肌梗死存活人群冠心病发病危险因素与胰岛素抵抗的关联

Relationship between risk factors of coronary heart disease and insulin resistance in the patients surviving myocardial infarction

目的：分析２２４例心肌梗死存活者中与胰岛素抵抗有关的冠心病发病危险因素分布及关联。结果：高血压、高血糖、高甘油三酯及低高密度脂蛋白胆固醇血症发生率分别为４９．１％，４７．３％，２８．１％及１２．１％。具有上述危险因素中０项、１项、２项及３（或以上）项的四组（Ａ、Ｂ、Ｃ、Ｄ组）之胰岛素敏感性（ＩＳ）呈逐渐下降趋势：设Ａ组ＩＳ为１．０，其余各组分别为０．８４、０．７４和０．５４，与前一组比较Ｐ＜０．０１、Ｐ＜０．０１、Ｐ＜０．００１。结论：本人群冠心病危险因素叠加程度与胰岛素抵抗严重程度密切相关。

Objective:This paper analysed the distribution of risk factors of coronary heat disease (CHD) related to insulin resistance in 224 survivors of myocardial infarction.Results: The frequency of hypertension, hyperglycemia, hyper triglyceridemia and low high density cholesterol were 49.1%, 47.3%, 28.1% and 12.1%, respectively. In the subgroups without or with 1, 2 or more than 3 CHD risk factors above mentioned (group A、 B、 C、 D), the insulin sensitivity (IS) was decreased as the number of risk factors increased. If the IS in group A was defined as 1.0, then the IS in group B、 C and D was 0.84, 0.74 and 0.54 respectively ( P <0 01, <0 01 and <0 001 compared with the group before it).Conclusion: Thus it indicatd that the clustering of risk factors of CHD was significantly related to the severity of IS in this population.