1-6二磷酸果糖对缺氧缺血性脑损伤线粒体形态变化及能量代谢的影响

Morphologic Changes of Mitochondria and Metabolic Effects of Fructose 1 6 Diphosphate in Hypoxic ischemic Brain Damage.

目的 探讨１６ 二磷酸果糖（ＦＤＰ）干预治疗新生鼠缺氧缺血性脑损伤（ＨＩＢＤ）后脑神经细胞线粒体形态学变化及对能量代谢的影响。 方法 用新生鼠ＨＩＢＤ 动物模型，在急性期给予ＦＤＰ干预治疗，缺氧缺血２１ 天后用透射电镜观察脑选择性易损区海马ＣＡ１ 区锥体细胞线粒体形态改变。 结果 缺氧缺血２１ 天后脑神经细胞部分线粒体形态异常。与缺氧缺血组相比，ＦＤＰ干预组线粒体病变减轻。 结论 缺氧缺血２１ 天线粒体有异常。ＦＤＰ干预治疗减轻了ＨＩＢＤ

Objective To study the morphologic changes of mitochondria and metabolic protective effect of fructose 1 6 diphosphate(FDP) intervention in newborn rats with hypoxic ischemic brain damage(HIBD). Methods Newborn rat HIBD model was set, intervened with FDP during acute phase, morphologic changes of mitochodria in hippocampal CA 1 of newborn rats after hypoxic ischemia 21 days were observed by transmission electron microscopy. Results Some mitochondria were abnormal in HIBD 21 days as compared with hypoxic ischemic group, morphologic changes of mitochondria in FDP intervention group was milder. Conclusion Morphologic changes of mitochondria are present after HIBD 21 days. FDP intervention decreases morphologic changes of mitochondria after HIBD, and may improve neuronic energy metabolism.