摘要
目的为2型糖尿病合并牙周病患者动脉粥样硬化的防治提供依据。方法采用彩超测定60例2型糖尿病合并牙周病患者(观察组)及50例无牙周病的糖尿病患者(对照组)的颈动脉内膜—中膜厚度(IMT);取其血液标本,葡萄糖氧化酶法测空腹血糖(FPG),ELISA法测定空腹胰岛素(FINS),酶比色法测定TG、TC、HDL-C、LDL-C,免疫比浊法测定C反应蛋白(CRP),ELISA法测定可溶性细胞间黏附分子-1(sICAM-1),同时计算BMI、胰岛素抵抗指数(HOMA-IR),对IMT与上述指标行Pearson相关分析和多元线性逐步回归分析。结果观察组FPG、FINS、TG、CRP、sICAM-1、IMT、HOMA-IR水平均明显高于对照组,而HDL-C水平明显低于对照组(P<0.05或P<0.01)。直线相关分析示IMT与年龄、FPG、TC、TG、LDL-C、FINS、HOMA-IR、CRP、sICAM-1、BMI呈正相关(P<0.05或P<0.01),与HDL-C呈负相关(P<0.01)。多元线性逐步回归分析示IMT与HOMA-IR、CRP、LDL-C呈正相关。结论血清CRP水平升高是影响2型糖尿病合并牙周病患者动脉粥样硬化的独立危险因素之一。
Objective To provide basis for the prevention and cure of atherosclerosis in patiens with type 2 diabetes mellitus and periodontitis.Methods The intima-media thickness(IMT) was examined in 60 patiens with type 2 diabetes mellitus and periodontitis(observed group) and 50 patiens with type 2 diabetes mellitus(control group);serum sample were taken from the two groups,the fasting plasma glucose(FPG) was detected by glucose oxidase method,the fasting insulin(FINS) was detected by ELISA method,and the total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C) were detected by enzymes colorimetric method,the C reactive protein(CRP) was detected by immunoturbidimetry method,the soluble cellular adhesion molecule-1(sICAM-1) was measured by ELISA method.Body mass index(BMI) and homeostasis model assessment of insulin resistance(HOMA-IR) were calculated.Pearson correlation analysis and multiple stepwise regression analysis were used.Results The levels of FPG,FINS,TG,CRP,sICAM-1,IMT,HOMA-IR in the observed group were significantly higher than those in the control group,and the level of HDL-C was significantly lower than that in the control group(P0.05 or P0.01).Pearson correlation analysis indicated that IMT was positively correlated with age,FPG,TC,TG,LDL-C,FINS,HOMA-IR,CRP,sICAM-1,BMI(P0.05 or P0.01),but was negative correlated with HDL-C(P0.01).Multiple stepwise regression analysis indicated that IMT was positively correlated with HOMA-IR,CRP and LDL-C were independent factors that affect IMT.Conclusions C reactive protein was a independent risk factor of atherosclerosis in patients with type 2 diabetes and periodontitis.
出处
《山东医药》
CAS
北大核心
2010年第43期1-3,共3页
Shandong Medical Journal
基金
广西壮族自治区教育厅资助项目(200710MS178)
桂林市科学研究与技术开发计划课题项目(20090545)
关键词
糖尿病
非胰岛素依赖型
牙周病
动脉粥样硬化
C反应蛋白
可溶性细胞间黏附分子
diabetes mellitus
non-insulin-dependent
periodontitis
atherosclerosis
C reactive protein
soluble intercellular adhesion molecule-1