牛磺酸对小鼠的镇痛作用研究

Analgesic Effect of Taurine in Mice

采用酒石酸锑钾诱导小鼠扭体反应,观察牛磺酸的镇痛效果;牛磺酸和纳络酮合用,探讨牛磺酸镇痛作用与阿片肽受体的关系;测定血清和腹腔液中PGE2、脑组织中NO含量,探讨牛磺酸镇痛作用的可能机制。结果表明,应用牛磺酸后,小鼠扭体次数明显减少,牛磺酸和纳络酮合用较单独使用牛磺酸小鼠扭体次数显著增加,牛磺酸可显著降低小鼠腹腔液和血清中PGE2、脑组织中NO的含量。表明牛磺酸具有良好的镇痛效果,其镇痛作用机制可能是通过减少体内前列腺素和NO的生成;另外,牛磺酸的镇痛作用可能与中枢阿片受体有一定关系。

Experimental algesimetry in mice model of writhing was used to observe the analgesic effects of taurine.The relationship between taurine and opioid peptide receptor was analyzed by allylnoroxymorphone.The mechanism of the analgesic effect of taurine was investigated by detecting the concentration of prostaglandin E2（PGE2） in the serum and ascites,and NO in the brain.The results showed that tautine can significantly reduce the frequency of writhing in mice.The frequency of writhing in mice obviously decreased when taurine combined with allylnoroxymorphone.Taurine can significantly decrease the levels of PGE2 and NO.The results indicated that taurine has marked analgesic effect.The analgesic effect of taurine may be realized by reducing the levels of PGE2 and NO,and closely associated with the receptor of opioid peptide.