强化区大小变化在肺癌非手术治疗疗效评价中作用的初步探讨

Preliminary Discussion on Efficacy of Size Change of Enhancement Region in Assessing Effect of Non-surgical Treatment of Pulmonary Cancer

目的:初步探讨强化区最大单径之和变化在评价肺癌非手术疗效中的作用。方法:22例经非手术治疗肺癌患者在治疗前及停止治疗1个月后行螺旋CT增强双期扫描。结果:治疗前、治疗后及治疗后90 s时病灶强化区最大单径之和差异有统计学意义(F=4.273,P=0.018)。治疗前病灶最大单径之和明显大于治疗后病灶强化区最大单径之和(P=0.005),与治疗后最大单径之和比较,差异无统计学意义(P=0.203)。治疗后最大单径之和与治疗后病灶强化区最大单径之和比较,差异无统计学意义(P=0.108)。结论:利用肿瘤最大单径之和变化来评价肺癌疗效会低估治疗效果,建议利用强化区最大单径之和变化来评价肺癌疗效。

Objective To analyze the efficacy of the changes of minimum total diameters of the enhancement area in assessing the effect of the no-surgical treatment of pulmonary tumor.Methods 22 patients with pulmonary tumors underwent two-phase enhanced spiral CT tomography prior to receiving no-surgical treatment and one month later after the treatment.Results The differences of the total minimum tumor diameters in enhanced area prior to and after treatment were statistically significant（F=4.273,P=0.018）.The total minimum tumor diameters prior to treatment are significantly greater than that of the post-treatment in the tumor enhancement area（P=0.005） with no statistically significant difference found between them（P=0.203）.There is no statistically significant difference between t the total minimum tumor diameters prior to treatment and that of after treatment（P=0.108）.Conclusion The paper suggests that using the changes of minimum total diameters of the enhancement area is an effective way for assessing the effect of the no-surgical treatment of pulmonary tumor.