室温条件下硝酸铋高效催化“一锅法”合成4(3H)-喹唑啉酮衍生物

One-pot synthesis of 4(3H)-quinazolinones derivatives catalyzed by bismuth nitrate at room temperature

4（3H）-喹唑啉酮及其衍生物具有抗疟疾、抗癌、抗痉挛、消炎、抗菌等多种生理活性。因此,该类化合物的合成引起了人们极大的兴趣。1895年,Niementowski发明了一种简单且易操作的合成4（3H）-喹唑啉酮的方法,该方法在1946年被Grimmel改进。

4（3H）-quinazolinones derivatives were synthesized efficiently by a three components one-pot reaction of anthranilic acid,ortho esters and amines catalyzed by bismuth nitrate at room temperature without solvent.The effects of different reaction conditions on the yields were investigated.The optimal conditions were as follows：nacid：nester：namine=1：1.2：1.2,Bi（NO3） 3·5H2O 1 mol%.This protocol had advantages of mild conditions,high yields,simple work-up,recyclable catalyst and environmental friendly procedure.The structures of products were characterized by IR,1H NMR and elemental analysis.