期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

FTO--肥胖相关新基因 被引量：3

FTO: A New Gene Related to Obesity
下载PDF
导出
摘要 FTO基因是最近发现的一个与肥胖相关的基因,广泛地分布于生物界中,在动物多种组织中均有表达,而在下丘脑中表达最高。FTO基因的表达产物是一种核酸修复酶,能作用于下丘脑弓状核,调节食欲和能量代谢。基因组关联分析发现:FTO基因内有许多单核苷酸多态性位点,这些单核苷酸多态性位点与肥胖和胰岛素敏感性有关,FTO基因的变异增加肥胖和2-型糖尿病的风险。FTO基因是肥胖和2型糖尿病的候选新基因。 FTO （fat mass and obesity associated） gene is new gene which was identified to be related to obesity in recent years. FTO gene widely presents in the bio-resources and expresses in various tissues, especially high in hypothalamus. The expressed product of FTO gene is a nuclease which acts on the hypothalamic arcuate nucleus and regulates appetite and energy metabolism. Genome-wide association study （GWAS） indicates that there are lots of single nucleotide polymorphism sites （SNPs） in FTO gene, these SNPs are associated with obesity and insulin sensitivity, variation of FTO gene increases the risk of obesity and type 2 diabetes. FTO gcne is considered as a new candidate gene related to obesity and type 2 diabetes.
作者 叶瑞松 万庆慧 赵素梅 高士争
机构地区 云南农业大学
出处 《云南农业大学学报（自然科学版）》 CAS CSCD 北大核心 2010年第6期879-883,共5页 Journal of Yunnan Agricultural University:Natural Science
基金 国家自然科学基金(30660132) 云南省自然科学基金重点项目(2005C0008Z)
关键词 FTO基因 肥胖 2-型糖尿病 fat mass and obesity associated gene obesity type 2 diabetes
分类号 Q756 [生物学—分子生物学]
  • 相关文献

参考文献29

  • 1PETERS T, AUSMEIER K, RUTHER U. Cloning of Fatso (FTO), a novel gene deleted by the Fused toes (Ft) mouse mutation [ J]. Mammalian Genome, 1999, 10 (10) : 983 -986.
  • 2STRATAKIS C A, LAFFERTY A, TAYMANS S E, et al. Anisomastia associated with interstitial duplication of chromosome 16, mental retardation, obesity, dysmorphic facies, and digital anomalies: molecular mapping of a new syndrome by fluorescent in situ hybridization and microsatellites to 16q13 (D16S419- D16S503) [J]. Journal of Clinical Endocrinology and Metabolism, 2000, 85 (9) : 3396 -3401.
  • 3FRAYLING T M, TIMPSON N J, WEEDON M N, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity [J]. Science, 2007, 316 (5826): 889-894.
  • 4STRATIGOPOULOS G, PADILLA S L, LEDUC C A. Regulation of FTO/Ftm gene expression in mice and humans [ J ]. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008, 295 (4) : 1360 - 1363.
  • 5MULLER T D, HINNEY A, SCHERAG A, et al. Fat mass and obesity associated gene (FTO) : no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents [ J]. BMC Medical Genetics, 2008, 17 (9): 85.
  • 6FAN B, DU Z Q, ROTHSCHILD M F. The fat mass and obesity-associated (FTO) gene is associated with intramuscular fat content and growth rate in the pig [ J]. Animal Biotechnology, 2009, 20 (2) : 58 - 70.
  • 7FREDRIKSSON R, HAGGLUND M, OLSZEWSKI P K, et al. The obesity gene, FTO, is of ancient origin, up- regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain [J]. Endocrinology, 2008, 149 (5): 2062-2071.
  • 8GERKEN T, GIRARD C A, TUNG Y C, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase [ J]. Science, 2007, 318 (5855): 1469 -1472.
  • 9SANCHEZ-PULIDO L, ANDRADE-NAVARRO M A. The FTO (fht mass and obesity associated) gene codes for a novel member of the non-heine dioxygenase superfamily [ J ]. BMC Biochemistry, 2007, 8 ( 1 ) : 23 - 28.
  • 10FREATHY R M, TIMPSON N J, LAWLOR D A, et al. Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect onBMl [J] Diabetes, 2008, 57 (5): 1419-1426.

同被引文献66

  • 1母义明,陈康.成人2型糖尿病胰岛素临床应用中国专家共识解读[J].中国医学前沿杂志（电子版）,2012,4(3):52-53. 被引量：5
  • 2王涤非,邱忠霞,张锦,蒋丽娟,蔡东梅,刘清利,丁梅.北方汉族2型糖尿病人胰岛素受体底物1基因多态性的研究[J].中国病理生理杂志,2005,21(4):793-796. 被引量：6
  • 3张莹,张代民,许会彬.糖尿病患者肝功能的变化及其意义[J].临床军医杂志,2005,33(2):151-152. 被引量：21
  • 4Pinney SE, Simmons RA. Epigenetic mechanisms in thedevelopment of type 2 diabetes [J]. Trends in Endocrinology andMetabolism, 2010,21 (4,SI): 223-229.
  • 5LI HX,GAN W,LU L,et al. A genome-wide association studyidentifies GRK5 and RASGRP1 as type 2 diabetes loci in ChineseHans [J]. Diabetes, 2013, 62 (l) : 291-298.
  • 6Baier LJ, Bogardus C, Sacchettini JC. A polymorphism in thehuman intestinal fatty acid binding protein alters fatty acid transportacross Caco-2 cells [j]. Journal of Biological Chemistry, 1996,271 (18): 10892-10896.
  • 7Small KS, Hedman AK, Grundberg E, et al. Identification of animprinted master trans regulator at the KLF14 locus related tomultiple metabolic phenotypes [J]. Nat Genet, 2011, 43 (6):561-564.
  • 8XU SH,JIN L. A genome-wide analysis of admixture in Uyghurs anda high-density admixture map for disease-gene discovery [J]. Am JHum Genet, 2008, 83 (3) : 322-336.
  • 9XU SH,YIN XY, LI SL,et al. Genomic dissection of populationsubstructure of Han Chinese and its implication in association studies[J]. Am J Hum Genet, 2009, 85 (6): 762-774.
  • 10萧建中,杨文英.中国南北地区糖尿病患病的异同和相关危险因素分析[C] //中华医学会糖尿病学分会第十六次全国学术会议论文集,成都,2012: 6-7.

引证文献3

二级引证文献12

云南农业大学学报（自然科学版）
2010年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部