辛伐他汀对急性冠脉综合征患者颈动脉粥样硬化的影响

Effects of simvastatin on carotid arteries atherosclerosis in patients with acute coronary syndrome

目的:探讨辛伐他汀对急性冠脉综合征患者颈动脉粥样硬化的影响及其机制。方法:80例急性冠脉综合征患者随机分成辛伐他汀20 mg组(40例)和辛伐他汀40 mg组(40例),于治疗前及治疗6个月后分别测定血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)水平,并超声检测颈动脉内-中膜厚度(IMT)及颈动脉斑块面积。结果:两组治疗后TC、TG、LDL-C水平均明显降低(P<0.01),HDL-C明显升高(P<0.01);而辛伐他汀40 mg组较20 mg组作用更为明显(P<0.05)。治疗6个月后IMT及颈动脉斑块面积明显缩小(P<0.01),且辛伐他汀40 mg组作用更显著(P<0.01)。结论:辛伐他汀对急性冠脉综合征患者颈动脉粥样硬化斑块具有延缓和稳定作用。

Objective：To investigate the effect and mechanism of simvastatin on carotid arteries atherosclerosis in patients with acute coronary syndrome. Methods ：Eighty patients with acute coronary syndrome were randomized into two groups ,simvastatin 20 mg group （treated with simvastatin 20 mg/d,n = 40）and simvastatin 40 mg group （treated with simvastatin 40 mg/d,n=40）. The serum total cholesterol（TC）,glycerin trilaurate （TG）,low density lipoprotein cholesterol （LDL-C）and high density tipoprotein cholesterol （HDL-C）was respectively determined before cure and 6 months after cure. Carotid artery intima-media thickness（IMT）and the plaque was measured by ultrasound and blood fat were observed. Results ：Six months after treatment with simvastatin 20 mg/d and 40 mg/d,the levels of TC,TG and LDL-C decreased significantly（P〈0.01）,while HDL-C increased significantly（P〈0. 01 ）. The effects brought by simvastatin 40 mg more significant than those brought by simvastatin 20 mg（P〈0. 05）. Six months after treatment with simvastatin,the IMT and the plaque decreased significantly （P〈0. 01） ,and the effects brought by simvastatin 40 mg more significant than those brought by simvastatin 20 mg （P〉0. 01）. Conclusion： Simvastatin is effective on carotid arteries atherosclerosis patients with acute coronary syndrome.