糖尿病患者肾脏动脉血流改变与糖尿病肾病的关系

The relationship between diabetic nephropathy and renal arterial blood flow change

目的探讨糖尿病患者肾内动脉血流动力学变化对糖尿病肾病(DN)诊断的临床价值。方法以24小时尿蛋白排泄率(UAER)作为DN的诊断指标,应用彩色多普勒血流显像技术对2型糖尿病患者54例行肾脏动脉血管超声检查,以20例同期健康体检者为正常对照,对其收缩期最大血流速度、舒张期末最低血流速度和阻力指数进行统计学分析。结果糖尿病组舒张末血流速度下降及血流阻力指数增高程度与正常对照组之间差异均有统计学意义(P<0.01);其中肾内各级动脉血流阻力指数增高与肾功能损害程度相关。结论彩色多普勒超声检测糖尿病患者肾血流动力学变化有助早期DN诊断及肾功能不全的判断。

Objective To explore the clinical value of renal arterial blood flow change for the diagnosis of diabetic nephropathy.Methods 24-hour urinary albumin protein excretion rate（UAER） was used as the diagnosis index of diabetic nephropathy.54 patients of Type 2 diabetes and 20 healthy people as normal control were examined by color doppler flow imaging（CDFI）.Results There were significant difference in the levels of decreased diastolic blood flow velocity and increased resistance index between diabetes group and normal control group.There was a close correlationship between increased arterial blood flow intro-renal resistance index and impairment of renal function.Conclusion The degree of diabetic nephropathy can be reflected by using CDFI in the patients of diabetes,which method has an important clinical value for the diagnosis of diabetic nephropathy.