高血压患者心功能与动脉僵硬度相关性研究

The relationship between arterial stiffness and cardiac function in patients with hypertension

目的探讨高血压患者动脉僵硬度与其心功能状态的相关性。方法 120例确诊高血压患者,其中男80例,女40例,平均年龄（64.9±10.4）岁（范围42-85岁）,按纽约心脏病协会心功能分级标准进行分级,根据不同的心功能分四组,心功能Ⅰ、Ⅱ、Ⅲ、Ⅳ级作为实验组,与实验组性别、年龄匹配的100例健康人作为健康对照组。采用脉搏波传导速度（PWV）自动测定系统对上述人群测定肱动脉-踝动脉脉搏波传导速度（BaPWV）作为反映动脉僵硬度的指标,比较正常人与不同心功能状态高血压患者间动脉僵硬度的差异。结果在调整了年龄、性别、血糖和血脂参数之后,分析结果显示：心功能与PWV值呈显著正相关（P〈0.01）,随心功能的恶化PWV值逐渐增加。正常人和纽约心功能Ⅰ、Ⅱ、Ⅲ、Ⅳ及患者的PWV值分别为（8.59±0.79）m/s,（10.02±1.31）m/s,（11.94±1.91）m/s,（14.68±1.38）m/s,（16.38±1.71）m/s。结论 PWV所反映的动脉僵硬度增加在高血压患者中与心功能状态恶化相关,改善动脉僵硬度可能对于改善高血压患者的心功能有益。

Objective To explore the relationship between arterial stiffness and cardiac function in patients with hypertension.Methods 120 hypertension patients with a mean age of（64.89±10.14）（range from 42 to 85）80 male and 40 female,and were divided into four groups,the cardiac function I,II,III,IV level as the experimental group,100 healthy people as normal control group according to the New York Heart Association cardiac function classification.Using automatic pulse wave velocity（PWV） system to determine all subjects carotid-femoral artery（BaPWV） as index to reflect arterial stiffness,compare difference of arterial stiffness among normal group and different cardiac function group.Results After adjusting age,sex,blood sugar and lipid level,the results demonstrated that cardiac function had positive relationship with BaPWV（P〈0.01）,the worse the cardiac function,the higher the PWV were.PWV in normal group,cardiac functionⅠ,Ⅱ,Ⅲ and Ⅳ group were（8.5±0.79） m/s,（10.02±1.31） m/s,（11.94±1.91） m/s,（14.68±1.38） m/s and（16.38±1.71） m/s,respectively.Conclusion Arterial stiffness reflected by PWV had close relationship with cardiac function in patients with hypertension,regression of arterial stiffness may be helpful for cardiac function.