水热法合成不同形貌羟基磷灰石

Hydroxyapatite particles with different morphologies synthesized by hydrothermal method

羟基磷灰石由于具有良好的生物相容性和生物活性而应用广泛,形貌控制对其应用至关重要。本文分别以Ca（NO3）2·4H2O、KH2PO4·3H2O为Ca源和P源,采用水热法制备不同形貌的羟基磷灰石。用X射线衍射（XRD）和扫描电镜（SEM）对反应产物进行表征,研究水热反应温度、水热反应时间和反应物浓度对羟基磷灰石形貌的影响。结果表明,不同条件下,产物为长径比不同的片状、带状及花状羟基磷灰石（HA）,其长度为1-100μm、宽1-5μm、厚约100 nm、长径比为1-100,并从晶体生长动力学方面探讨不同合成条件对羟基磷灰石形貌的影响机理。

Hydroxyapatite has been widely used because of its excellent biocompatibility and bioactivity,and the morphology control is of critical importance for its usage.In the present paper,hydroxyapatite particles with different morphologies were synthesized through hydrothermal method,using Ca（NO3）2.4H2O and KH2PO4.3H2O as the Ca and P sources,respectively.The effects of hydrothermal temperature,time and concentration of reactants as well on the morphology were studied.The products were charaterized by X-ray diffraction（XRD） and scanning electron microscope（SEM）.The results show that plate-like,ribbon-like and flower-like hydroxyapatite with length of 1-100 μm,width of 1-5 μm and thickness of about 100 nm,length-diameter ratio of 1-100 were synthesized under different conditions.In addition,the mechanism of morphology control through crystal growth dynamics was also discussed.