小儿慢性腹痛与幽门螺杆菌感染关系探讨

Relationship between children chronic abdominal pain and helicobacter pylori infection

目的：探讨小儿慢性腹痛与幽门螺杆菌（HP）感染的关系，为慢性腹痛患儿提供部分病因诊断和治疗的依据。方法：采用血清HP－lgG定量测定或胃内容物及齿槽分泌物PCR基因检测HP－DNA，对185名3岁～14岁慢性上中腹、脐周痛为临床表现患儿进行监测。并随机选出其中32名进行钡透及胃镜对照检查。结果：185名患儿中HP感染占51．9％，并随年龄增长而增高。HP（＋）者100％引起上消化道慢性炎症或溃疡。治论：小儿慢性腹痛与HP感染有密切关系。HP感染→胃炎→溃疡→慢性腹痛是构成小儿中上胶、脐周痛疼的病因链。HP的检测是小儿慢性腹痛病因诊断和治疗首选筛查手段。

Objective: The purpose of this paper was to study the relationship between children chronic abddominal pain(CCAP) and helicobacter Pylori(Hp) infection. Methods: The serum Hp IgG of 185 3 - 14 yeare old patients with upper and middle parit abdominal pain and pain around umbilicus was measured by ELISA and Hp - DNA in gastric juice and saliva was determined by PCR testin upper and middle pants with abdominal pain and pain areund umbiliclds,35 patients of whom randomly selected were examined by upper GI endoscopy and Ba meal fluroscopy. Results: The postive percentage was 51. 9% in 185 patients, postively cormlating with age, and 100% the patients with Hp(+) all developed upper GI chronic inflammaton or uler. Conclusion: It is demonstrated that CCAP has a intimate relation to Hp infection, and it is sugysted that the pathogenic chain of CCAn probably is Hp infection→ gastritis→uler→chronic abdominal pain.