益肾、健脾和柔肝中药抗炎镇痛作用的比较研究

A Comparative Study of Kidney-tonifying Formula,Spleen-reinforcing and Liversoftening Formula for Anti-inflammation and Analgesia Effect

目的：比较治疗ＯＡ常用的益肾方、健脾方和柔肝方的抗炎镇痛效应。方法：以小鼠热反法缩腿反应、耳廓肿胀度及佐剂性关节炎大鼠的踝关节肿胀指数为指标，观察益肾方、健脾方和柔肝方的抑炎镇痛效应。结果：益肾方、健脾方和柔肝方提高痛阈分别为４４．６％、１０６．７％、１４５．６％；肿胀抑制率分别为８．２％、６６．７％、７２．６％。结论：健脾方和柔肝方对急性和亚急性炎症有较好的抑炎镇痛作用，益肾方无明显抑炎镇痛效应。

Objetive:To compare the effects of anti-inflammation and analgesia with Kidney-tomifying Formula(KTF),Spleen-reinforcing Formula(SRF) and Liver-softening Formula(LSF) on the mice and rats.Methods:The effect of anti-inflammation and analgesia of KTF,SRF and LSF were observed with methods of hot plate test,auricular swelling test on mice and ankle swelling scores on adjuvant induced arthritis (AIA) rats.Results:The pain threshold of three group (KTF,SRF and LSF) were increased 44.6%、106.7%、145.6% respectively:The swelling depressive rate were 8.2%、66.7%、72.6% respectively.Conclusions:A good results of anti-inflammation and anagesia effect were observed in two groups treated with SRF and LSF、KTF had no difference with control group.