PBS/壳聚糖复合材料表面选择性激光刻蚀PBS的研究

Research on selective laser PBS ablation from PBS/chitosan composites surface

为了改善聚丁二酸丁二醇酯poly-(butylene succinate)-壳聚糖复合材料的表面生物学性能,进行193nm激光刻蚀该复合材料的研究,以提高该复合材料的表面生物活性.采用表面轮廓仪、表面水接触角分析仪、扫描电镜、红外衰减全反射研究改性后材料表面的特性;并采用DNA分析的方法分析材料表面细胞的生物学特性.研究结果表明,复合材料表面与本体的激光刻蚀能量阈值分别为59mJ/cm2和125mJ/cm2.图像定量分析表明随着刻蚀次数的增加,表面壳聚糖累计面积从0.9mm2增加到4.5mm2,达到其本体复合的比例.表面水接触角随着刻蚀次数的增加从91度减少到28度.细胞学实验表明刻蚀后表面的壳聚糖促进了成骨细胞在复合材料表面的粘附及生长.用激光表面选择性刻蚀可以提高复合材料表面生物活性的成分从而改善其生物活性.

A 193 nm laser was used to ablate poly-（butylene succinate）（PBS） from the PBS/chitosan composite surface to improve the composite biocompatibility.In this article,surface profiler meter,water contact measure meter,SEM,FT-IR were used to prove a chitosan rich surface achieved.The results showed the composite surface and bulk laser ablation thresholds were 59 mJ/cm^2 and 125 mJ/cm^2,respectively.The chitosan area increased from 0.9 mm2 to 4.5 mm^2 close to the bulk composite mixing ratio after ablation.The water contact angle decreased from 91 to 29 degree after ablation.The better cell adhesion and proliferation behavior after ablation was the result of more bioactive chitosan content on surface.This article showed the laser selective ablation could be used to increase the bioactive content on composite surface to improve its biocompatibility.