BATPPH_2及其Zn配合物与环糊精的超分子体系研究

Supramolecular Systems of BATPPH_2 and Its Zn Complex with Cyclodextrins

设计合成了5-(4-苯甲酰亚胺基苯基)-10,15,20-三苯基卟啉(BATPPH2)及其锌配合物(BATPPZn),并通过1HNMR、IR、UV-Vis、元素分析等方法对化合物的结构加以确认。在中性磷酸盐缓冲溶液中,以荧光光谱法、紫外可见分光光度法和1HNMR法分别研究了BATPPH2和BATPPZn与α,β,γ-环糊精相互作用形成的超分子体系。利用双倒数曲线法计算了BATPPH2-CD和BATPPZn-CD超分子体系的包结常数,结果表明BATPPH2和BATPPZn与γ-CD的包结常数(K1γ-CD,K2γ-CD)最大,γ-CD表现出最强的包结能力,Zn2+的配位作用使包结物的稳定性降低。

s： A new porphyrin 5-（4-Benzamido Phenyl）-10, 15, 20-triphenylporphyrin （BATPPH2） and its Zn complex （BATPPZn） were synthesized and characterized by elemental analyses, IR, UV-Vis spectra and 1↑H NMR respectively. In neutral phosphate buffer solution, the inclusive complexation behavior of BATPPH2 and BATPPZn with α- cyclodextrin（α-CD）, β-cyclodextrin （β-CD）, and γ-cyclodextrin （γ-CD） have been examined by means of Ultraviolet-visible spectrometry and fluorescence spectroscopy. The formation constants （K） of BATPPH2 and BATPPZn for the inclusion complexes have been estimated from the absorbance and fluorescence intensity changes. The Kγ-CD value （7.20 ×10^5） of BATPPH2-γ-CD is bigger than that of the other two CDs, that indicates γ-CD have the strongest inclusion ability, zinc ion coordination destabilizes the inclusion complex of porphyrin and cyclodextrin. In addition 1H NMR data and 2D-NOESY spectra support the inclusion conformation of the supramolecular system（BATPPH2-γ- CD and BATPPZn-γ-CD）.