摘要
目的评价D2+腹主动脉旁淋巴结清扫(D4)术治疗进展期胃癌的临床疗效与安全性。方法电子检索Cochrane图书馆的Cochrane对照试验注册数据库(2009年第2期),PubMed,MEDLINE,EMBASE,CBM,CNKI,VIP,万方数据资源的D2和D4淋巴结清扫治疗进展期胃癌的相关文献(截至2009年4月)。由2名评价者独立评价并交叉核对纳入研究的质量,对同质研究采用RevMan5.0软件进行Meta分析。结果共纳入有D2和D4淋巴清扫的对照研究4个,包括1120例患者。D2和D4两种淋巴清扫术治疗进展期胃癌,患者术后生存率无统计学意义(P>0.05);两组的5年复发率,术后病死率,手术并发症发生率也无统计学差异(均P>0.05)。结论 D2和D4两种淋巴结清扫术治疗进展期胃癌的临床效果相似。鉴于纳入研究在方法学上的局限性,尚难最后结论。
Objective To assess the efficacy and safety of D2＋paraaortic lymph node dissection （LND） （D4） for patients with advanced gastric cancer.Methods We searched the electronic bibliographic databases,including Cochrane library,Pubmed,EMBASE,CBM,VIP,CNKI and WABNGFANG to assemble the RCT of D2 and D4 LND for patients with advanced gastric cancer.The deadline retrieval time was October 2009.Data were extracted and evaluated by two reviewers independently.The RevMan 5.0 software was used for data analysis.Results Four randomized trials involving 1120 patients were included.The results indicated that compared with D4 LND,D4 LND dissection did not increase the patient＇s survival rate,and there was no significant difference in the cancer recurrence rate after operation,postoperative mortality or the incidence of complications between the D2 and D4 LND.Conclusions Because of the limitations of the included studies,the efficacy and safety of D2 and D4 LND for patients with advanced gastric cancer could not be accurately assessed.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2010年第10期1085-1090,共6页
China Journal of General Surgery
基金
兰州大学2010年"君政基金"
